Maternal iron intake at mid-pregnancy is associated with reduced fetal growth: results from Mothers and Children’s Environmental Health (MOCEH) study

Nutrition Journal

Namsoo Chang³  Yun-Chul Hong²  Yangho Kim⁶  Mina Ha⁴  Hyesook Park⁵  Eun-Hee Ha⁵  Hyesook Kim³  Ki-Nam Kim³  Ji-Yeon Lee³  Ji-Yun Hwang¹ 

[1] Graduate School of Education, Sangmyung University, Seoul, 110-743, Korea;Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, 110-799, Korea;Department of Nutritional Science and Food Management, Ewha Womans University, Seoul, 120-750, Korea;Department of Preventive Medicine, Dankook University College of Medicine, Cheonan, 330-715, Korea;Department of Preventive Medicine, College of Medicine, Ewha Womans University, Seoul, 158-710, Korea;Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, 682-060, Korea

关键词: MOCHE study;    Diet;    Growth;    Pregnancy;    Iron;   

Others  :  807047
DOI  :  10.1186/1475-2891-12-38

 received in 2012-03-31, accepted in 2013-03-21,  发布年份 2013

【 摘 要 】

Background

Iron supplementation is a common recommendation for pregnant women to prevent iron deficiency during pregnancy. There is an increasing concern about excessive iron consumption as a general iron prophylaxis by pregnant women without any due consideration about their dietary iron intake or iron status. Our present study investigated the association between total iron intake from diet and supplements and fetal growth in 337 pregnant women at mid-pregnancy in South Korea.

Methods

Iron intake from diet and supplements was examined by a 24-hour recall method. Subjects were divided into three groups based on tertiles of total iron intake levels. Fetal biometry was assessed by ultrasonography at mid-pregnancy.

Results

About 99% of the non-supplement users had iron intake below the recommended nutrient intake (RNI) for pregnant women (24 mg), whereas 64.9% of supplement users had iron intake above the upper level (UL) (45 mg). In the babies of mothers in the third tertile of iron intake (>17.04 mg), biparietal diameter, abdominal circumference, and femur length were lower by 0.41 cm (P =0.019), 0.41 cm (P = 0.027), and 0.07 cm (P = 0.051), respectively, than the babies of mothers in the second tertile of iron intake (11.49 ~ 17.04 mg).

Conclusion

These results suggest that excessive maternal iron intake at mid-pregnancy is associated with reduced fetal growth. Iron supplementation for pregnant women should be individualized according to their iron status. Appropriate diet education is needed for pregnant women so that they can consume adequate amounts of iron from food and supplements.

【 授权许可】

   
2013 Hwang et al.; licensee BioMed Central Ltd.

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