Wide distribution and ancient evolutionary history of simian foamy viruses in New World primates

Retrovirology

William M. Switzer⁵  Joel M. Montgomery¹  Matthew R. Kasper³  Daniel G. Bausch⁶  Patricia Mendoza²  Aris Katzourakis⁴  Pakorn Aiewsakun⁴  Hongwei Jia⁵  Bruno M. Ghersi³ 

[1] Centers for Disease Control and Prevention, Atlanta 30333, GA, USA;Wildlife Conservation Society, Lima, Peru;U.S. Naval Medical Research Unit No. 6, Lima, Peru;Department of Zoology, University of Oxford, Oxford OX1 3PS, UK;Laboratory Branch, Division of HIV/AIDS Prevention, National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, 1600 Clifton Rd., MS G-45, Atlanta 30329, GA, USA;Tulane School of Public Health and Tropical Hygiene, New Orleans, LA, USA

关键词: Neotropical;    Peru;    South America;    Nonhuman primates;    Co-speciation;    Co-evolution;    Simian foamy virus;    Retrovirus;   

Others  :  1230916
DOI  :  10.1186/s12977-015-0214-0

 received in 2015-04-28, accepted in 2015-10-04,  发布年份 2015

【 摘 要 】

Background

Although simian foamy viruses (SFV) are the only exogenous retroviruses to infect New World monkeys (NWMs), little is known about their evolutionary history and epidemiology. Previous reports show distinct SFVs among NWMs but were limited to small numbers of captive or wild monkeys from five (Cebus, Saimiri, Ateles, Alouatta, and Callithrix) of the 15 NWM genera. Other studies also used only PCR testing or serological assays with limited validation and may have missed infection in some species. We developed and validated new serological and PCR assays to determine the prevalence of SFV in blood specimens from a large number of captive NWMs in the US (n = 274) and in captive and wild-caught NWMs (n = 236) in Peruvian zoos, rescue centers, and illegal trade markets. Phylogenetic and co-speciation reconciliation analyses of new SFV polymerase (pol) and host mitochondrial cytochrome B sequences, were performed to infer SFV and host co-evolutionary histories.

Results

124/274 (45.2 %) of NWMs captive in the US and 59/157 (37.5 %) of captive and wild-caught NWMs in Peru were SFV WB-positive representing 11 different genera (Alouatta, Aotus, Ateles, Cacajao, Callithrix, Cebus, Lagothrix, Leontopithecus, Pithecia, Saguinus and Saimiri). Seroprevalences were lower at rescue centers (10/53, 18.9 %) compared to zoos (46/97, 47.4 %) and illegal trade markets (3/7, 8/19, 42.9 %) in Peru. Analyses showed that the trees of NWM hosts and SFVs have remarkably similar topologies at the level of species and sub-populations suggestive of co-speciation. Phylogenetic reconciliation confirmed 12 co-speciation events (p < 0.002) which was further supported by obtaining highly similar divergence dates for SFV and host genera and correlated SFV-host branch times. However, four ancient cross-genus transmission events were also inferred for Pitheciinae to Atelidae, Cacajao to ancestral Callithrix or Cebus monkeys, between Callithrix and Cebus monkeys, and Lagothrix to Alouatta.

Conclusions

We demonstrate a broad distribution and stable co-speciation history of SFV in NWMs at the species level. Additional studies are necessary to further explore the epidemiology and natural history of SFV infection of NWMs and to determine the zoonotic potential for persons exposed to infected monkeys in captivity and in the wild.

【 授权许可】

   
2015 Ghersi et al.

【 图 表 】

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