NF-kappaB activation: Tax sumoylation is out, but what about Tax ubiquitination?

Retrovirology

Gutian Xiao¹ 

[1] University of Pittsburgh Cancer Institute, University of Pittsburgh Medical Centers, Pittsburgh, PA 15213, USA

关键词: Ubiquitin;    Tumroigenesis;    Taxisome;    Tax;    SUMO;    Retrovirus;    Nuclear body;    NF-κB;    Leukemia;    HTLV;    IKK;    ATL;   

Others  :  1209264
DOI  :  10.1186/1742-4690-9-78

 received in 2012-08-13, accepted in 2012-09-05,  发布年份 2012

【 摘 要 】

Activation of the NF-κB transcription factors by the viral protein Tax plays a vital role in the pathogenesis of diseases associated with human T-cell lymphotropic virus type I (HTLV-I). The Tax oncoprotein undergoes constitutive K63-linked ubiquitination and sumoylation; however, the roles and molecular mechanisms of these post-translational modifications in Tax-mediated NF-κB activation are being debated. Here, we discuss our current understanding of Tax activation of NF-κB, with a focus on the controversies and the challenges that we are facing.

【 授权许可】

   
2012 Xiao; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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