期刊论文详细信息
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Mortality in severely injured elderly patients: a retrospective analysis of a German level 1 trauma center (2002–2011)
Sven Lendemans1  Bjoern Hussmann1  Alexander Wegner1  Marc Schilling1  Thomas Probst2  Carsten Schoeneberg1 
[1] Department of Trauma Surgery, University Hospital Essen, University Duisburg-Essen, Hufelandstraße 55, Essen 45147, Germany;Department of Trauma, Orthopedic, and Hand Surgery, Municial Hospital Neuss, Lukashospital GmbH, Preußenstraße 84, Neuss 41464, Germany
关键词: Severely injured;    Elderly patients;    Mortality rate;    Trauma;   
Others  :  1152086
DOI  :  10.1186/s13049-014-0045-3
 received in 2014-05-02, accepted in 2014-07-28,  发布年份 2014
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【 摘 要 】

Background

Demographic change is expected to result in an increase in cases of severely injured elderly patients. To determine special considerations in treatment and outcome, patients aged 75 years and older were studied.

Methods

All patients in the included age group with an Injury Severity Score (ISS) ≥ 16 upon primary admission to hospital between July 2002 and December 2011 were included in this mortality analysis. The data used for this study was gained partly from data submitted to the German Trauma Register and partly from patients’ hospital records. A comparison between survivors and decedents was performed, as well as age-adjusted and ISS-adjusted analyses. The odds ratio and relative risk were used to determine predictors for mortality.

Results

One-hundred eight patients met the inclusion criteria. The overall mortality proportion was 57.4%. The decedents were more severely injured (ISS 26 vs. 20, p < 0.001) and suffered more severe head traumas (GCS 4 vs. 12, p < 0.001; AIS head 5 vs. 4, p = 0.006). No differences were found in vital parameters measured at the accident scene or trauma room. Decedents had deranged coagulation with a prolonged PTT (41.1 sec vs. 27.6 sec, p = 0.008) and reduced prothrombin ratio (66.5% vs. 82.8%, p = 0.016).

Only 17.1% of patients presenting an ISS > 25 survived, suggesting that an injury of such severity is hardly survivable in the subject age group.

Predictors for mortality were: ISS > 25, GCS < 9, PTT > 32.4 seconds, prothrombin ratio < 70%, AIS head > 3, and Hb < 12 g/dl.

Conclusions

The treatment of severely injured elderly patients is challenging. The most common cause of accident is falling from less than 3 m with head injuries being determinant. We identified deranged coagulopathy as an important predictor for mortality, suggesting rapid normalization of coagulation might be a key to reducing mortality.

【 授权许可】

   
2014 Schoeneberg et al.; licensee BioMed Central Ltd.

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【 参考文献 】
  • [1][https:/ / www.destatis.de/ DE/ Publikationen/ Thematisch/ Bevoelkerung/ Bevoelkerungsstand/ AlterimWandel.html] webcite Bevölkerung - Alter im Wandel - Ältere Menschen in Deutschland und der EU - Statistisches Bundesamt (Destatis).] Accessed April 2014.
  • [2]Sampalis JS, Nathanson R, Vaillancourt J, Nikolis A, Liberman M, Angelopoulos J, Krassakopoulos N, Longo N, Psaradellis E: Assessment of mortality in older trauma patients sustaining injuries from falls or motor vehicle collisions treated in regional level I trauma centers. Ann Surg 2009, 249:488-495.
  • [3]Goodmanson NW, Rosengart MR, Barnato AE, Sperry JL, Peitzman AB, Marshall GT: Defining geriatric trauma: When does age make a difference? Surgery 2012, 152:668-675.
  • [4]Shifflette VK, Lorenzo M, Mangram AJ, Truitt MS, Amos JD, Dunn EL: Should age be a factor to change from a level II to a level I trauma activation? J Trauma 2010, 69:88-92.
  • [5]Taylor MD, Tracy JK, Meyer W, Pasquale M, Napolitano LM: Trauma in the elderly: intensive care unit resource use and outcome. J Trauma 2002, 53:407-414.
  • [6]Newell MA, Rotondo MF, Toschlog EA, Waibel BH, Sagraves SG, Schenarts PJ, Bard MR, Goettler CE: The elderly trauma patient: an investment for the future? J Trauma 2009, 67:337-340.
  • [7]Dinh MM, Roncal S, Byrne CM, Petchell J: Growing trend in older patients with severe injuries: mortality and mechanisms of injury between 1991 and 2010 at an inner city major trauma centre. ANZ J Surg 2013, 83:65-69.
  • [8]Scalea TM, Simon HM, Duncan AO, Atweh NA, Sclafani SJ, Phillips TF, Shaftan GW: Geriatric blunt multiple trauma: improved survival with early invasive monitoring. J Trauma 1990, 30:129-134. discussion 134–6
  • [9]Victorino GP, Chong TJ, Pal JD: Trauma in the elderly patient. Arch Surg 2003, 138:1093-1098.
  • [10]Lehmann R, Beekley A, Casey L, Salim A, Martin M: The impact of advanced age on trauma triage decisions and outcomes: a statewide analysis. Am J Surg 2009, 197:571-574. discussion 574–5
  • [11]Martin JT, Alkhoury F, O’Connor JA, Kyriakides TC, Bonadies JA: ‘Normal’ vital signs belie occult hypoperfusion in geriatric trauma patients. Am Surg 2010, 76:65-69.
  • [12]Baker SP, O’Neill B, Haddon W, Long WB: The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma 1974, 14:187-196.
  • [13]Osler T, Baker SP, Long W: A modification of the injury severity score that both improves accuracy and simplifies scoring. J Trauma 1997, 43:922-925. discussion 925–6
  • [14]Teasdale G, Jennett B: Assessment of coma and impaired consciousness. A practical scale. Lancet 1974, 2:81-84.
  • [15]Champion HR, Sacco WJ, Carnazzo AJ, Copes W, Fouty WJ: Trauma score. Crit Care Med 1981, 9:672-676.
  • [16]Lefering R: Development and validation of the revised injury severity classification score for severely injured patients. Eur J Trauma Emerg Surg 2009, 35:437-447.
  • [17]Schoeneberg C, Schilling M, Keitel J, Kauther MD, Burggraf M, Hussmann B, Lendemans S: TraumaNetwork, Trauma Registry of the DGU(R), Whitebook, S3 Guideline on Treatment of Polytrauma/Severe Injuries - An Approach for Validation by a Retrospective Analysis of 2304 Patients (2002–2011) of a Level 1 Trauma Centre.Zentralbl Chir 2014, Epub ahead of print.
  • [18]Richmond TS, Kauder D, Strumpf N, Meredith T: Characteristics and outcomes of serious traumatic injury in older adults. J Am Geriatr Soc 2002, 50:215-222.
  • [19]Pathak A, Dutta S, Marwaha N, Singh D, Varma N, Mathuriya SN: Change in tissue thromboplastin content of brain following trauma. Neurol India 2005, 53:178-182.
  • [20]Joseph B, Aziz H, Zangbar B, Kulvatunyou N, Pandit V, O’Keeffe T, Tang A, Wynne J, Friese RS, Rhee P: Acquired coagulopathy of traumatic brain injury defined by routine laboratory tests: which laboratory values matter? J Trauma Acute Care Surg 2014, 76:121-125.
  • [21]Carrick MM, Tyroch AH, Youens CA, Handley T: Subsequent development of thrombocytopenia and coagulopathy in moderate and severe head injury: support for serial laboratory examination. J Trauma 2005, 58:725-729. discussion 729–30
  • [22][http:/ / www.awmf.org/ fileadmin/ user_upload/ Leitlinien/ 012_D_Ges_fuer_Unfallchirurgie/ 012-019e_S3_Severe_and_Multiple_Inj uries_2012-11.pdf] webcite German Trauma Society (DGU): S3 – guideline on treatment of patients with severe and Multiple Injuries. Accessed April 2014.
  • [23]Ley EJ, Clond MA, Srour MK, Barnajian M, Mirocha J, Margulies DR, Salim A: Emergency Department Crystalloid Resuscitation of 1.5 L or more is Associated with increased mortality in elderly and nonelderly trauma patients. J Trauma 2011, 70:398-400.
  • [24]Salottolo KM, Mains CW, Offner PJ, Bourg PW, Bar-Or D: A retrospective analysis of geriatric trauma patients: venous lactate is a better predictor of mortality than traditional vital signs. Scand J Trauma Resusc Emerg Med 2013, 21:7. BioMed Central Full Text
  • [25]Majetschak M, Christensen B, Obertacke U, Waydhas C, Schindler AE, Nast-Kolb D, Schade FU: Sex differences in posttraumatic cytokine release of endotoxin-stimulated whole blood: relationship to the development of severe sepsis. J Trauma 2000, 48:832-839. discussion 839–40
  • [26]Schoeneberg C, Kauther MD, Hussmann B, Keitel J, Schmitz D, Lendemans S: Gender-specific differences in severely injured patients between 2002 and 2011: data analysis with matched-pair analysis. Crit Care 2013, 17:R277. BioMed Central Full Text
  • [27]Frink M, Pape H, van Griensven M, Krettek C, Chaudry IH, Hildebrand F: Influence of sex and age on mods and cytokines after multiple injuries. Shock 2007, 27:151-156.
  • [28]Schönenberger A, Billeter AT, Seifert B, Neuhaus V, Trentz O, Turina M: Opportunities for improved trauma care of the elderly – A single center analysis of 2090 severely injured patients. Arch Gerontol Geriatr 2012, 55:660-666.
  • [29]Giannoudis PV, Harwood PJ, Court-Brown C, Pape HC: Severe and multiple trauma in older patients; incidence and mortality. Injury 2009, 40:362-367.
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