Clinical manifestation, serology marker & microscopic agglutination test (MAT) to mortality in human leptospirosis

1st International Conference on Tropical Medicine and Infectious Diseases (ICTROMI) Faculty of Medicine Universitas Sumatera Utara

Perdhana, S.A.P.^1 ; Susilo, R.S.B.^1 ; Arifin^1 ; Redhono, D.^1 ; Sumandjar, T.^1

Tropical Medicine and Infectious Diseases Sub Division, Department of Internal Medicine, Sebelas Maret University (UNS), Moewardi Hospital, Surakarta, Indonesia^1

关键词: Agglutination tests;    Clinical manifestation;    Heavy rainfall;    Human infection;    Mortality rate;    Potentially fatal;    Tropical regions;   

Others  :  https://iopscience.iop.org/article/10.1088/1755-1315/125/1/012042/pdf
DOI  :  10.1088/1755-1315/125/1/012042

来源: IOP

【 摘 要 】

Leptospirosis is a potentially fatal zoonosis that is endemic in many tropical regions and causes large epidemics after heavy rainfall and flooding. Severe disease is estimated 5-15% of all human infections. Its mortality rate is 5-40%. MAT, isolation of the organism, or leptospiral DNA in PCR are used to confirm Leptospirosis. This cross-sectional analytic study recruited 26 hospitalized leptospirosis patients admitted to Dr. Moewardi Hospital Surakarta. The diagnosis was based on clinical, laboratory and epidemiological findings. The onset of the disease was the date when the first symptom started, and the end of the analysis was the date when the patient died or discharged. Modified Faine's score ≥ 25 tend to die (45.5%) while modified Faine's score 20 - 24 tend to heal (60%) (OR 1.250; CI 0.259-6.029; p=1.0). Seropositive IgM predicts mortality 7.8 times higher than seronegative IgM (OR 7.800; CI 1.162-52.353; p=0.038). MAT positive predict mortality 10.667 times higher than MAT negative (OR 10.667; CI 1.705-66.720; p=0.015). Clinical manifestation, MAT, and serologic marker are all correlated with mortality in Leptospirosis. However, statistically, clinical manifestation has an insignificant correlation.