Survey of enterovirus infections from hand, foot and mouth disease outbreak in china, 2009

Virology Journal

Qi Jin²  Zhifang Li³  Xiuhua Sun⁴  Shaoxia Sun³  Yufen Li³  Jiang Du²  Xiaofang Wang¹  Yongfeng Hu²  Ting Zhang²  Fan Yang² 

[1] Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, PRC;State Key Laboratory for Molecular Virology and Genetic Engineering, Institute of Pathogen Biology, Chinese Academy of Medical Sciences, Beijing, People's Republic of China;LinYi People's Hospital, Linyi, Shandong, PRC;Heze Center for Disease Control and Prevention, Heze, Shandong, PRC

关键词: coxsackie virus B5;    coxsackie virus A16;    human enterovirus 71;    enterovirus;    Foot and Mouth Disease;    Hand;   

Others  :  1155661
DOI  :  10.1186/1743-422X-8-508

 received in 2011-05-11, accepted in 2011-11-06,  发布年份 2011

【 摘 要 】

Background

In China, a rapid expansion of Hand, foot, and mouth disease (HFMD) outbreaks has occurred since 2004 and HFMD has become an important issue for China. However, people are still only concerned with human enterovirus 71(HEV-71) and coxsackie virus A16 (CV-A16). Much of what is known about the other enterovirus infections relies on fractional evidence and old epidemic data, with little knowledge concerning their distribution. To alert potential threatens of the other enteroviruses, our study genetically characterized specimens from different regions of China and yielded novel information concerning the circulating and phylogenetic characteristics of enteroviral strains from HFMD cases.

Findings

A total of 301 clinical throat swabs were randomly obtained from patients suffering from HFMD from the southern, northern and central regions of China during outbreaks in 2009. 266 of 301 (88.4%) HFMD cases were found positive for HEV and seven genotypes, HEV-71, CV-A16, -B5, -A4, -A6, -A10, and -A12, were detected.

Conclusions

The HFMD pathogen compositions in the different regions of China were significantly different. HFMD epidemics might persist for a long time in China due to the multiple pathogen compositions, the enteroviral characteristic of recombination and co-infection, the ever-increasing travel and migration and the deficiency of effective vaccine. Our study deserves the attention on HFMD control and vaccine development.

【 授权许可】

   
2011 Yang et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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