Epigenetic regulation of adult neural stem cells: implications for Alzheimer’s disease

Molecular Neurodegeneration

Bart PF Rutten¹  Daniel LA van den Hove⁵  Paul D Coleman⁶  Paul J Lucassen⁶  Jonathan Mill²  Diego F Mastroeni²  Katie Lunnon²  Harry WM Steinbusch⁵  Samia Joca³  Caroline Biojone³  Marco P Boks⁴  Mark van den Hurk⁵  Gunter Kenis⁵  Konstantinos Kompotis⁵  Roy Lardenoije⁵  Marijn Schouten⁶  Emma van Bodegraven⁶  Carlos P Fitzsimons⁶ 

[1] Department of Psychiatry and Neuropsychology, School for Mental Health and Neuroscience, Maastricht University Medical Centre, P.O. Box 616, 6200 MD Maastricht, The Netherlands;University of Exeter Medical School, RILD Level 4, Barrack Road, University of Exeter, Devon, UK;School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, São Paulo, Brazil;Department Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands;Department of Translational Neuroscience, School of Mental Health and Neuroscience (MHENS), Maastricht University, Maastricht, the Netherlands;Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, SciencePark 904, 1098XH Amsterdam, The Netherlands

关键词: Induced pluripotent stem cell;    Stem cell;    MicroRNAs;    Histone modifications;    DNA methylation;    Alzheimer’s disease;    Epigenetics;    Adult neurogenesis;   

Others  :  861312
DOI  :  10.1186/1750-1326-9-25

 received in 2014-05-10, accepted in 2014-06-06,  发布年份 2014

【 摘 要 】

Experimental evidence has demonstrated that several aspects of adult neural stem cells (NSCs), including their quiescence, proliferation, fate specification and differentiation, are regulated by epigenetic mechanisms. These control the expression of specific sets of genes, often including those encoding for small non-coding RNAs, indicating a complex interplay between various epigenetic factors and cellular functions.

Previous studies had indicated that in addition to the neuropathology in Alzheimer’s disease (AD), plasticity-related changes are observed in brain areas with ongoing neurogenesis, like the hippocampus and subventricular zone. Given the role of stem cells e.g. in hippocampal functions like cognition, and given their potential for brain repair, we here review the epigenetic mechanisms relevant for NSCs and AD etiology. Understanding the molecular mechanisms involved in the epigenetic regulation of adult NSCs will advance our knowledge on the role of adult neurogenesis in degeneration and possibly regeneration in the AD brain.

【 授权许可】

   
2014 Fitzsimons et al.; licensee BioMed Central Ltd.

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