Alternative Splicing Modulates Stem Cell Differentiation

Cell Transplantation

Article

Hsiu-Hui Yu¹  Kuo-Wei Li¹  Shih-Ping Liu²  Woei-Cherng Shyu³  Ru-Huei Fu³  Shinn-Zong Lin⁴  Chang-Hai Tsai⁵  Chen-Wei Ou⁶ 

[1] Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan;Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan;Graduate Institute of Basic Medical Science, China Medical University, Taichung, Taiwan;Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan;Graduate Institute of Immunology, China Medical University, Taichung, Taiwan;Center for Neuropsychiatry, China Medical University Hospital, Taichung, Taiwan;Graduate Institute of Immunology, China Medical University, Taichung, Taiwan;China Medical University Beigang Hospital, Yunlin, Taiwan;Department of Pediatrics, China Medical University Hospital, Taichung, Taiwan;Department of Healthcare Administration, Asia University, Taichung, Taiwan;Graduate Institute of Immunology, China Medical University, Taichung, Taiwan;

关键词: Alternative splicing;    Stem cell;    mRNA;    Posttranscriptional regulation;    Induced pluripotent stem cell;   

DOI  :  10.3727/096368909X471260

来源: Sage Journals

【 摘 要 】

Stem cells have the surprising potential to develop into many different cell types. Therefore, major research efforts have focused on transplantation of stem cells and/or derived progenitors for restoring depleted diseased cells in degenerative disorders. Understanding the molecular controls, including alternative splicing, that arise during lineage differentiation of stem cells is crucial for developing stem cell therapeutic approaches in regeneration medicine. Alternative splicing to allow a single gene to encode multiple transcripts with different protein coding sequences and RNA regulatory elements increases genomic complexities. Utilizing differences in alternative splicing as a molecular marker may be more sensitive than simply gene expression in various degrees of stem cell differentiation. Moreover, alternative splicing maybe provide a new concept to acquire induced pluripotent stem cells or promote cell–cell transdifferentiation for restorative therapies and basic medicine researches. In this review, we highlight the recent advances of alternative splicing regulation in stem cells and their progenitors. It will hopefully provide much needed knowledge into realizing stem cell biology and related applications.

【 授权许可】

Unknown   
© 2009 Cognizant Comm. Corp.

【 图 表 】

Figure 2.