Nutrition Journal | |
Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study | |
Susan S Percival2  Christina Khoo1  James Colee3  Rebecca Creasy2  Catherine Muller2  Cheryl A Rowe2  Meri P Nantz2  | |
[1] Ocean Spray Cranberries, Inc., Lakeville, MA 02349, USA;Department of Food Science & Human Nutrition, University of Florida, Box 110370, Gainesville, FL 32611, USA;Department of Statistics, University of Florida, Gainesville, FL 32611, USA | |
关键词: NK cell; γδ-T cell; Immunity; Proanthocyanidins; Cranberry; | |
Others : 801961 DOI : 10.1186/1475-2891-12-161 |
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received in 2013-09-25, accepted in 2013-12-09, 发布年份 2013 | |
【 摘 要 】
Background
Our main objective was to evaluate the ability of cranberry phytochemicals to modify immunity, specifically γδ-T cell proliferation, after daily consumption of a cranberry beverage, and its effect on health outcomes related to cold and influenza symptoms.
Methods
The study was a randomized, double-blind, placebo-controlled, parallel intervention. Subjects drank a low calorie cranberry beverage (450 ml) made with a juice-derived, powdered cranberry fraction (n = 22) or a placebo beverage (n = 23), daily, for 10 wk. PBMC were cultured for six days with autologous serum and PHA-L stimulation. Cold and influenza symptoms were self-reported.
Results
The proliferation index of γδ-T cells in culture was almost five times higher after 10 wk of cranberry beverage consumption (p <0.001). In the cranberry beverage group, the incidence of illness was not reduced, however significantly fewer symptoms of illness were reported (p = 0.031).
Conclusions
Consumption of the cranberry beverage modified the ex vivo proliferation of γδ-T cells. As these cells are located in the epithelium and serve as a first line of defense, improving their function may be related to reducing the number of symptoms associated with a cold and flu.
Trial registration
ClinicalTrials.gov Identifier:NCT01398150.
【 授权许可】
2013 Nantz et al.; licensee BioMed Central Ltd.
【 预 览 】
Files | Size | Format | View |
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20140708014135635.pdf | 248KB | download | |
Figure 1. | 52KB | Image | download |
【 图 表 】
Figure 1.
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