Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study

Nutrition Journal

Susan S Percival²  Christina Khoo¹  James Colee³  Rebecca Creasy²  Catherine Muller²  Cheryl A Rowe²  Meri P Nantz² 

[1] Ocean Spray Cranberries, Inc., Lakeville, MA 02349, USA;Department of Food Science & Human Nutrition, University of Florida, Box 110370, Gainesville, FL 32611, USA;Department of Statistics, University of Florida, Gainesville, FL 32611, USA

关键词: NK cell;    γδ-T cell;    Immunity;    Proanthocyanidins;    Cranberry;   

Others  :  801961
DOI  :  10.1186/1475-2891-12-161

 received in 2013-09-25, accepted in 2013-12-09,  发布年份 2013

【 摘 要 】

Background

Our main objective was to evaluate the ability of cranberry phytochemicals to modify immunity, specifically γδ-T cell proliferation, after daily consumption of a cranberry beverage, and its effect on health outcomes related to cold and influenza symptoms.

Methods

The study was a randomized, double-blind, placebo-controlled, parallel intervention. Subjects drank a low calorie cranberry beverage (450 ml) made with a juice-derived, powdered cranberry fraction (n = 22) or a placebo beverage (n = 23), daily, for 10 wk. PBMC were cultured for six days with autologous serum and PHA-L stimulation. Cold and influenza symptoms were self-reported.

Results

The proliferation index of γδ-T cells in culture was almost five times higher after 10 wk of cranberry beverage consumption (p <0.001). In the cranberry beverage group, the incidence of illness was not reduced, however significantly fewer symptoms of illness were reported (p = 0.031).

Conclusions

Consumption of the cranberry beverage modified the ex vivo proliferation of γδ-T cells. As these cells are located in the epithelium and serve as a first line of defense, improving their function may be related to reducing the number of symptoms associated with a cold and flu.

Trial registration

ClinicalTrials.gov Identifier:NCT01398150.

【 授权许可】

   
2013 Nantz et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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