Acute oxygen sensing: diverse but convergent mechanisms in airway and arterial chemoreceptors

Respiratory Research

Paul J Kemp¹  Chris Peers¹ 

[1] University of Leeds, Leeds, UK

关键词: O₂ sensing;    neuroepithelial body;    hypoxia;    chemoreceptor;    carotid body;   

Others  :  1227455
DOI  :  10.1186/rr51

 received in 2001-02-20, accepted in 2001-03-01,  发布年份 2001

【 摘 要 】

Airway neuroepithelial bodies sense changes in inspired O₂, whereas arterial O₂ levels are monitored primarily by the carotid body. Both respond to hypoxia by initiating corrective cardiorespiratory reflexes, thereby optimising gas exchange in the face of a potentially deleterious O₂ supply. One unifying theme underpinning chemotransduction in these tissues is K⁺ channel inhibition. However, the transduction components, from O₂ sensor to K⁺ channel, display considerable tissue specificity yet result in analogous end points. Here we highlight how emerging data are contributing to a more complete understanding of O₂ chemosensing at the molecular level.

【 授权许可】

   
2001 BioMed Central Ltd

【 图 表 】

Figure 1.

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