Asthma and PM10

Respiratory Research

William MacNee²  M Ian Gilmour¹  Kenneth Donaldson² 

[1] Experimental Toxicology Division, US Environmental Protection Agency, Research Triangle Park, North Carolina USA;Edinburgh Lung and the Environment Group Initiative Colt Research Laboratories, University of Edinburgh, Medical School, Edinburgh, UK

关键词: PM10;    exacerbation;    asthma;    air pollution;   

Others  :  1227496
DOI  :  10.1186/rr5

 received in 2000-05-19, accepted in 2000-06-23,  发布年份 2000

【 摘 要 】

PM₁₀ (the mass of particles present in the air having a 50% cutoff for particles with an aerodynamic diameter of 10 μm) is the standard measure of particulate air pollution used worldwide. Epidemiological studies suggest that asthma symptoms can be worsened by increases in the levels of PM₁₀. Epidemiological evidence at present indicates that PM₁₀ increases do not raise the chances of initial sensitisation and induction of disease, although further research is warranted. PM₁₀ is a complex mixture of particle types and has many components and there is no general agreement regarding which component(s) could lead to exacerbations of asthma. However pro-inflammatory effects of transition metals, hydrocarbons, ultrafine particles and endotoxin, all present to varying degrees in PM₁₀, could be important. An understanding of the role of the different components of PM₁₀ in exacerbating asthma is essential before proper risk assessment can be undertaken leading to advice on risk management for the many asthmatics who are exposed to air pollution particles.

【 授权许可】

   
2000 Current Science Ltd

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