Plasma uric acid and tumor volume are highly predictive of outcome in nasopharyngeal carcinoma patients receiving intensity modulated radiotherapy

Radiation Oncology

Wei-Han Hu¹  Rui Sun¹  Hong-Zhi Wang¹  Nan Ge²  Huan-Xin Lin¹  Hui Lin¹ 

[1] State Key Laboratory of Oncology in South China, Guangdong Province, Guangzhou, 510060, China;Surgical Intensive Care Unit, Xiangtan Central Hospital, Hunan Province, Xiangtan, 411100, China

关键词: Prognosis;    Tumor volume;    Plasma uric acid;    Nasopharyngeal carcinoma;    Intensity-modulated radiotherapy;   

Others  :  1153942
DOI  :  10.1186/1748-717X-8-121

 received in 2012-12-18, accepted in 2013-05-08,  发布年份 2013

【 摘 要 】

Background

The combined predictive value of plasma uric acid and primary tumor volume in nasopharyngeal carcinoma (NPC) patients receiving intensity modulated radiation therapy (IMRT) has not yet been determined.

Methods

In this retrospective study, plasma uric acid level was measured after treatment in 130 histologically-proven NPC patients treated with IMRT. Tumor volume was calculated from treatment planning CT scans. Overall (OS), progression-free (PFS) and distant metastasis-free (DMFS) survival were compared using Kaplan-Meier analysis and the log rank test, and Cox multivariate and univariate regression models were created.

Results

Patients with a small tumor volume (<27 mL) had a significantly better DMFS, PFS and OS than patients with a large tumor volume. Patients with a high post-treatment plasma uric acid level (>301 μmol/L) had a better DMFS, PFS and OS than patients with a low post-treatment plasma uric acid level. Patients with a small tumor volume and high post-treatment plasma uric acid level had a favorable prognosis compared to patients with a large tumor volume and low post-treatment plasma uric acid level (7-year overall OS, 100% vs. 48.7%, P <0.001 and PFS, 100% vs. 69.5%, P <0.001).

Conclusions

Post-treatment plasma uric acid level and pre-treatment tumor volume have predictive value for outcome in NPC patients receiving IMRT. NPC patients with a large tumor volume and low post-treatment plasma uric acid level may benefit from additional aggressive treatment after IMRT.

【 授权许可】

   
2013 Lin et al.; licensee BioMed Central Ltd.

【 图 表 】

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