The oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi

Particle and Fibre Toxicology

Hu Pan¹  Zhiqiang Yang¹  Jianxi Li¹  Xuezhi Wang¹  Xiaolou Miao¹  Dongsheng Wang¹  Xiaofei Shang¹ 

[1] Key Laboratory of Veterinary Pharmaceutical Development, Ministry of Agriculture, Lanzhou Institute of Husbandry and Pharmaceutical Sciences of Chinese Academy of Agricultural Science, Lanzhou 730050, People's Republic of China

关键词: Inflammatory factor;    Superoxide dismutase;    Oxidative status;    Psoroptes cuniculi;    Rabbits;   

Others  :  809649
DOI  :  10.1186/1756-3305-7-124

 received in 2014-01-17, accepted in 2014-03-12,  发布年份 2014

【 摘 要 】

Background

Psoroptes cuniculi can parasitise the ear canal of the rabbit, and cause the afflicted animals to cease feeding and become severely debilitated, sometimes resulting in death. In this study, we examined the oxidative status and inflammatory level of the peripheral blood of rabbits infested with Psoroptes cuniculi and investigated the pathogenesis of this disease.

Methods

A total of 24 rabbits were divided into a healthy rabbit group and two infested rabbit groups. After weighing the rabbits, approximately 5 ml of blood was obtained from each animal. Then, the blood serum was extracted and used to assess the levels of antioxidant enzymes and inflammatory factors.

Results

Compared to the healthy rabbits, the activities of catalase and glutathione-S-transferase and the level of malonyldialdehyde were increased, but the activity of superoxide dismutase was reduced in the infested rabbits. At the same time, a variety of inflammatory cells were activated, and the levels of inflammatory factors such as prostaglandin E₂, interleukin-6, interleukin-8 and transforming growth factor-β1 were increased in peripheral blood.

Conclusion

Animal acariasis was associated with immunosuppressive disorders and inflammatory reaction. These results advance our understanding of the pathogenesis of Psoroptes cuniculi infestation in rabbits and can help guide the effectual treatment of this disease in clinics.

【 授权许可】

   
2014 Shang et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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