Evaluation of the efficacy of bendiocarb in indoor residual spraying against pyrethroid resistant malaria vectors in Benin: results of the third campaign

Particle and Fibre Toxicology

Martin Akogbéto²  Anges Yadouléton¹  Olivier Oussou¹  Gil Germain Padonou²  Rock Aikpon²  Razaki Ossè² 

[1] Centre de Recherche Entomologique de Cotonou (CREC), 06 BP 2604, Cotonou, Bénin;Faculté des Sciences et Techniques, Université d’Abomey Calavi, Calavi, Bénin

关键词: Benin;    Resistance;    Bendiocarb;    IRS;    Longevity;    EIR;    An.gambiae;   

Others  :  1231725
DOI  :  10.1186/1756-3305-5-163

 received in 2012-05-10, accepted in 2012-07-29,  发布年份 2012

【 摘 要 】

Background

Since 2008, the National Malaria Control Program (NMCP) has been engaged in the implementation of indoor residual spraying (IRS) in Benin. The first and second round was a success with a drastic decrease of malaria transmission in areas under IRS. We present here the results of the third round. The purpose of this study was to compare the results of the third round of IRS to those achieved during the first two rounds. A second success of IRS will enable the Government of Benin to extend the strategy to other areas.

Methods

Mosquito collections were carried out in the department of Ouémé where the homes of four districts were treated with bendiocarb. In these districts, more than 350 000 inhabitants were protected by IRS. A fifth untreated district served as control. In the five districts, mosquito collections were organized to follow the dynamics of malaria transmission and possible changes in the behavior of mosquitoes.

Results

A significant reduction in human biting rate was recorded after the third round of IRS, specifically in Adjohoun (89.78%), Dangbo (56.8%) and Missérété (93.22%) where an inhabitant received less than 2 bites of An. gambiae per night. During this same time, the entomological inoculation rate (EIR) declined dramatically in all areas under intervention (74.26% reduction). We also noted a significant reduction in longevity, the blood feeding rate of the vectors and an increase in exophily induced by bendiocarb on An. gambiae and Mansonia spp.

Conclusion

The present study showed, once again, the effectiveness of bendiocarb on anopheles populations resistant to pyrethroids. This product can be recommended in combination with other insecticides for the management of vector resistance to insecticides.

【 授权许可】

   
2012 Ossè et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1 .

【 参考文献 】

• [1]World Malaria Report. World Health Organization, Geneva, Switzerland; 2011. http://www.who.int/malaria/world_malaria_report_2011/en/ webcite (accessed 21.05.2012)
• [2]Ministère de la Santé: Annuaire des statistiques sanitaires 2006. Direction de la Programmation et de la Prospective, Cotonou; 2007.
• [3]Elissa N, Mouchet J, Rivière F, Meunier JY, Yao K: Resistance of Anopheles gambiae s.s. to pyrethroids in Côte d’Ivoire. Ann Soc Belge Med Trop 1993, 73:291-294.
• [4]Akogbéto M, Yakoubou S: Résistance des vecteurs du paludisme vis-à-vis des pyréthrinoïdes utilisés pour l’imprégnation des moustiquaires au Bénin, Afrique de l’Ouest. Bull Soc Path Exo 1999, 92:123-130.
• [5]Chandre F, Manguin S, Brengues C, Dossou Yovo J, Darriet F, Diabate A, Carnevale P, Guillet P: Current distribution of a pyrethroid resistance gene (kdr) in Anopheles gambiae complex from West Africa and further evidence for reproductive isolation of the Mopti form. Parassitologia 1999, 41:319-322.
• [6]Yadouleton AW, Padonou G, Asidi A, Moiroux N, Banganna S, Corbel V, N'guessan R, Gbenou D, Yacoubou I, Gazard K, Akogbeto MC: Insecticide resistance status in Anopheles gambiae in southern Benin. Malar J 2010, 9:83. BioMed Central Full Text
• [7]Stump AD, Atieli FK, Vulule JM, Besansky NJ: Dynamics of the pyrethroid knockdown resistance allele in western Kenyan populations of Anopheles gambiae in response to insecticide-treated bed net trials. Am J Trop Med Hyg 2004, 70:591-596.
• [8]Etang J, Fondjo E, Chandre F, Morlais I, Brengues C, Nwane P, Chouaibou M, Ndjemai H, Simard F: First report of knockdown mutations in the malaria vector Anopheles gambiae from Cameroon. Am J Trop Med Hyg 2006, 74:795-797.
• [9]Hargreaves K, Koekemoer L, Brooke BD, Hunt RH, Mthembu J, Coetzee M: Anopheles funestus resistant to pyrethroid insecticides in South Africa. Med Vet Entomol 2000, 14:181-189.
• [10]Hargreaves K, Hunt RH, Brooke BD, Mthembu J, Weeto MM, Awolola TS, Coetzee M: Anopheles arabiensis and An. quadriannulatus resistance to DDT in South Africa. Med Vet Entomol 2003, 17:417-422.
• [11]N'Guessan R, Corbel V, Akogbeto M, Rowland M: Reduced efficacy of insecticide treated nets and indoor residual spraying for malaria control in pyrethroid resistance area, Benin. Emerg Infect Dis 2007, 13:99-206.
• [12]Rowland M: Rapport RBM/WIN Meeting. , Basel, Switzerland; 2007:24-26. http://www.rollbackmalaria.org/partnership/wg/wg_itn/docs/rbmwin4ppt/4-4.pdf  webcite(accessed 17.11.2008)
• [13]Djènontin A, Bio-Bangana S, Moiroux N, Henry MC, Bousari O, Chabi J, Ossè R, Koudénoukpo S, Corbel V, Akogbéto M, Chandre F: Culicidae diversity, malaria transmission and insecticide resistance alleles in malaria vectors in Ouidah-Kpomasse-Tori district from Benin (West Africa): A pre-intervention study. Parasit Vectors 2010, 3:83. BioMed Central Full Text
• [14]Akogbéto M, Padonou G, Bankolé H, Kindé Gazard D, Gbédjissi G: Dramatic decline of malaria transmission after implementation of large-scale Indoor Residual Spraying using bendiocarb in Bénin, West Africa, an area of high Anopheles gambiae resistance to pyrethroids. Am J Trop Med Hyg 2011, 85(4):586-593.
• [15]Zaim M, Guillet P: Alternative insecticides: an urgent need. Trends parasitol 2002, 18:161-163.
• [16]Akogbéto M, Padonou G, Gbénou D, Irish S, Yadouleton A: Bendiocarb, a potential alternative against pyrethroid resistantAnopheles gambiaein Benin. West Africa. Malar J 2010, 9:204. BioMed Central Full Text
• [17]Gillies MT, De Meillon D: The Anophelinae of Africa South of the Sahara. Publ South Afri Inst Med Res 1968, 54:343.
• [18]Gillies MT, Coetzee MA: Supplement to the Anophelinae of Africa South of the Sahara, 2nd edn. Publ South Afri Inst Med Res 1987, 55:143.
• [19]Detinova TS, Gillies MT: Observations on the Determination of the Age Composition and Epidemiological Importance of Populations of Anopheles gambiae Giles and Anopheles funestus Giles in Tanganyika. Bull World Health Organ 1964, 30:23-28.
• [20]Wirtz RA, Ballou WR, Schneider I, Chedid L, Gross MJ, Young JF, Hollingdale M, Diggs CL, Hockmeyer WT: Plasmodium falciparum: immunogenicity of circumsporozoite protein constructs produced in Escherichia coli. Exp Parasitol 1987, 63:166-172.
• [21]Scott JA, Brogdon WG, Collins FH: Identification of single specimens of the Anopheles gambiae complex by the polymerase chain reaction. Am J Trop Med Hyg 1993, 49:520-529.
• [22]Favia G, Lanfrancotti A, Spanos L, Siden Kiamos I, Louis C: Molecular characterization of ribosomal DNA polymorphisms discriminating among chromosomal forms of Anopheles gambiae s.s. Insect Mol Biol 2001, 10:19-23.
• [23]Padonou GG, Sezonli M, Ossè R, Aizoun N, Oke-Agbo F, Oussou O, Gbedjissi G, Akogbéto M: Impact of three years of large scale Indoor Residual Spraying (IRS) and Insecticide Treated Nets (ITNs) interventions on insecticide resistance in Anopheles gambiae s.l. in Benin. Parasit Vectors 2012, 5:72. BioMed Central Full Text
• [24]Corbel V, N’Guessan R, Brengues C, Chandre F, Djogbenou L, Martin T, Akogbeto M, Hougard JM, Rowland M: Multiple insecticide mechanisms in Anopheles gambiae and Culex quinquefasciatus from Benin, West Africa. Acta Trop 2007, 101:207-216.
• [25]Akobgéto M: Etude des aspects épidémiologiques du paludisme côtier lagunaire au Bénin. Thèse de doctorat, Université de Paris XI; 1992.
• [26]Akogbéto M, Modiano D, Bosman A: Malaria transmission in the lagunar area of Cotonou (Benin). Parassitologia 1992, 34:147-154.
• [27]Dossou-Yovo J, Doannio JM, Diarrassouba S, Chauvancy G: Impact d’aménagements de rizières sur la transmission du paludisme dans la ville de Bouaké, Côte d’Ivoire. Bull Pathol Exot 1998, 91:327-333.
• [28]Dolo A, Camara F, Poudiougo B, Touré A, Kouriba B, Bagayogo M, Sangaré D, Diallo M, Bosman A, Modiano D, Touré YT, Doumbo O: Epidémiologie du paludisme dans un village de savane soudanienne du Mali (Bancoumana)-Etude entomo-parasitologique et clinique. Bull Soc Pathol Exot 2003, 96:308-312.
• [29]Sharp BL, Ridl FC, Govender D, Kuklinski J, Kleinschmidt I: Malaria vector control by indoor residual insecticide spraying on the tropical island of Bioko. Equatorial Guinea. Malar J 2007, 6:52. BioMed Central Full Text
• [30]Asidi AN, N' Guessan R, Koffi AA, Curtis CF, Hougard JM, Chandre F, Corbel V, Darriet F, Zaim M, Rowland MW: Experimental hut evaluation of bednets treated with an organophosphate (chlorpyrifos-methyl) or a pyrethroid (lambdacyhalothrin) alone and in combination against insecticide-resistant Anopheles gambiae and Culex quinquefasciatus mosquitoes. Malaria J 2005, 4:25. BioMed Central Full Text
• [31]Darriet F, N’Guessan R, Hougard J-M, Traoré-Lamizana M, Carnevale P: An experimental tool essential for the evaluation of insecticides: the testing huts. Bull Soc Pathol Exot 2002, 95:299-303.
• [32]N’Guessan R, Boko P, Odjo A, Chabi J, Akogbeto M, Rowland M: Control of pyrethroid and DDT resistant Anopheles gambiae by application of indoor residual spraying or mosquito nets treated with a long-lasting organophosphate insecticide, chlorpyrifos-methyl. Malaria J 2010, 9:44. BioMed Central Full Text