Modern radiation therapy and potential fertility preservation strategies in patients with cervical cancer undergoing chemoradiation

Radiation Oncology

Simone Marnitz²  Andreas Jantke¹  Christhardt Köhler¹  Volker Budach²  Pirus Ghadjar² 

[1] Department of Gynecology, Charité Universitätsmedizin Berlin, Berlin, Germany;Department of Radiation Oncology, Charité Universitätsmedizin Berlin, Augustenburger Platz 1, Berlin, 13353, Germany

关键词: Chemotherapy;    Fertility preservation;    Radiation therapy;    Cervical cancer;   

Others  :  1139719
DOI  :  10.1186/s13014-015-0353-4

 received in 2014-09-16, accepted in 2015-02-05,  发布年份 2015

【 摘 要 】

Young patients with cervical cancer who undergo chemoradiation might be interested in fertility preservation, not only dependent upon the use of a gestational carrier as maybe achieved by the use of ovarian transposition and cryo-conservation of oocytes or ovarian tissue, but may prefer to carry pregnancy to term after cancer treatment. The latter approach is a non-established concept needing both modern radiation therapy approaches as well as modifications -if at all possible- in current recommendations for target volume delineation to spare dose to the unaffected uterus. Future strategies to serve selected patients in this respect should only be conducted in prospective clinical evaluations and are critically discussed in this article.

【 授权许可】

   
2015 Ghadjar et al.; licensee BioMed Central.

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