S1 is associated with chronic low back pain: a functional and structural MRI study

Molecular Pain

Randy L Gollub²  Ajay D Wasan¹  Jordan W Smoller³  Vitaly Napadow²  Marco L Loggia²  Danhong Wang³  Hesheng Liu³  Ying Tan³  Karin Jensen³  Amanda H Cook³  Alexandra Cheetham³  Hsiao-Ying Wey²  Rosa B Spaeth³  Jian Kong² 

[1] Departments of Anesthesiology and Psychiatry, Brigham and Women’s Hospital, Harvard Medical School, Chestnut Hill, MA USA;A.A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA USA;Department of Psychiatry, Massachusetts General Hospital, Charlestown, Harvard Medical School, 120 2nd Ave., Room 101, Charlestown, MA 02129, USA

关键词: Primary somatosensory cortex;    Cortical thickness;    Functional connectivity;    fMRI;    Chronic low back pain;   

Others  :  862303
DOI  :  10.1186/1744-8069-9-43

 received in 2013-03-25, accepted in 2013-08-09,  发布年份 2013

【 摘 要 】

A fundamental characteristic of neural circuits is the capacity for plasticity in response to experience. Neural plasticity is associated with the development of chronic pain disorders. In this study, we investigated 1) brain resting state functional connectivity (FC) differences between patients with chronic low back pain (cLBP) and matched healthy controls (HC); 2) FC differences within the cLBP patients as they experienced different levels of endogenous low back pain evoked by exercise maneuvers, and 3) morphometric differences between cLBP patients and matched HC. We found the dynamic character of FC in the primary somatosensory cortex (S1) in cLBP patients, i.e., S1 FC decreased when the patients experienced low intensity LBP as compared with matched healthy controls, and FC at S1 increased when cLBP patients experienced high intensity LBP as compared with the low intensity condition. In addition, we also found increased cortical thickness in the bilateral S1 somatotopically associated with the lower back in cLBP patients as compared to healthy controls. Our results provide evidence of structural plasticity co-localized with areas exhibiting FC changes in S1 in cLBP patients.

【 授权许可】

   
2013 Kong et al.; licensee BioMed Central Ltd.

【 图 表 】

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