The CROWN initiative: journal editors invite researchers to develop core outcomes in women’s health

Reproductive Health

José M Belizán¹  Khalid Khan² 

[1] Institute for Clinical Effectiveness and Health Policy (IECS), Buenos Aires, Argentina;BJOG: An International Journal of Obstetrics and Gynaecology, London, UK

关键词: Consensus;    Evidence-based medicine;    Bias (Epidemiology);    Guidelines;    Systematic reviews;    Clinical trials;    Endpoint determination/standards;    Treatment outcome;    Research design/standards;   

Others  :  1146307
DOI  :  10.1186/1742-4755-11-42

 received in 2014-06-06, accepted in 2014-06-06,  发布年份 2014

【 摘 要 】

Clinical trials, systematic reviews and guidelines compare beneficial and non-beneficial outcomes following interventions. Often, however, various studies on a particular topic do not address the same outcomes, making it difficult to draw clinically useful conclusions when a group of studies is looked at as a whole. This problem was recently thrown into sharp focus by a systematic review of interventions for preterm birth prevention, which found that among 103 randomised trials, no fewer than 72 different outcomes were reported. There is a growing recognition among clinical researchers that this variability undermines consistent synthesis of the evidence, and that what is needed is an agreed standardised collection of outcomes - a "core outcomes set" - for all trials in a specific clinical area. Recognising that the current inconsistency is a serious hindrance to progress in our specialty, the editors of over 50 journals related to women's health have come together to support The CROWN (CoRe Outcomes in WomeN's health) Initiative.

【 授权许可】

   
2014 Khan and Belizan; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

【 参考文献 】

• [1]Williamson PR, Altman DG, Blazeby JM, Clarke M, Devane D, Gargon E, Tugwell P: Developing core outcome sets for clinical trials: issues to consider. Trials 2012, 13:132. BioMed Central Full Text
• [2]Meher S, Alfirevic Z: Choice of primary outcomes in randomised trials and systematic reviews evaluating interventions for preterm birth prevention: a systematic review. BJOG 2014. 10.1111/1471-0528
• [3]Williamson PR, Altman DG, Blazeby JM, Clarke M, Gargon E: The COMET (core outcome measures in effectiveness trials) initiative. Trials 2011, 12(Suppl 1):A70. BioMed Central Full Text