Genetic control of Aedes aegypti: data-driven modelling to assess the effect of releasing different life stages and the potential for long-term suppression

Particle and Fibre Toxicology

Christl A Donnelly³  Andrew R McKemey⁴  Luke Alphey⁵  Norzahira Raduan²  Jessica Stevenson⁴  Siân A Morgan⁴  Angela F Harris¹  Peter Winskill⁴ 

[1] Vector Group, Liverpool School of Tropical Medicine, Liverpool, UK;Institute for Medical Research, Jalan Pahang, 50588 Kuala Lumpur, Malaysia;Department of Infectious Disease Epidemiology, Medical Research Council Centre for Outbreak Analysis and Modelling, Faculty of Medicine, Imperial College London, St Mary’s Campus, London, UK;Oxitec Limited, Oxford, UK;Department of Zoology, University of Oxford, Oxford, UK

关键词: Pupae;    SIT;    Sterile insect technique;    Transgenic;    RIDL;    Dengue;    Aedes aegypti;   

Others  :  814026
DOI  :  10.1186/1756-3305-7-68

 received in 2013-10-14, accepted in 2014-01-27,  发布年份 2014

【 摘 要 】

Background

Control of the world’s most important vector-borne viral disease, dengue, is a high priority. A lack of vaccines or effective vector control methods means that novel solutions to disease control are essential. The release of male insects carrying a dominant lethal (RIDL) is one such approach that could be employed to control Aedes aegypti. To maximise the potential of RIDL control, optimum release strategies for transgenic mosquitoes are needed. The use of field data to parameterise models allowing comparisons of the release of different life-stages is presented together with recommendations for effective long-term suppression of a wild Ae. aegypti population.

Methods

A compartmental, deterministic model was designed and fitted to data from large-scale pupal mark release recapture (MRR) field experiments to determine the dynamics of a pupal release. Pulsed releases of adults, pupae or a combination of the two were simulated. The relative ability of different release methods to suppress a simulated wild population was examined and methods to maintain long-term suppression of a population explored.

Results

The pupal model produced a good fit to field data from pupal MRR experiments. Simulations using this model indicated that adult-only releases outperform pupal-only or combined releases when releases are frequent. When releases were less frequent pupal-only or combined releases were a more effective method of distributing the insects. The rate at which pupae eclose and emerge from release devices had a large influence on the relative efficacy of pupal releases. The combined release approach allows long-term suppression to be maintained with smaller low-frequency releases than adult- or pupal-only release methods.

Conclusions

Maximising the public health benefits of RIDL-based vector control will involve optimising all stages of the control programme. The release strategy can profoundly affect the outcome of a control effort. Adult-only, pupal-only and combined releases all have relative advantages in certain situations. This study successfully integrates field data with mathematical models to provide insight into which release strategies are best suited to different scenarios. Recommendations on effective approaches to achieve long-term suppression of a wild population using combined releases of adults and pupae are provided.

【 授权许可】

   
2014 Winskill et al.; licensee BioMed Central Ltd.

【 图 表 】

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