Exercise training with negative pressure ventilation improves exercise capacity in patients with severe restrictive lung disease: a prospective controlled study

Respiratory Research

Kang-Yun Lee³  Chun-Hua Wang²  Wen-Ching Jao²  Te-Fang Sheng²  Li-Fei Chen²  Han-Pin Kuo³  Horng-Chyuan Lin²  Shu-Chuan Ho¹ 

[1] School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan;Department of Thoracic Medicine, Chang Gung Memorial Hospital, Chang Gung University College of Medicine, 199 Tun-Hwa North Road, Taipei, Taiwan;Chang Gung University, Department of Medicine, College of Medicine, Taoyuan, Taiwan

关键词: Health-related quality of life;    Exercise capacity;    Exercise training;    Negative pressure ventilation;    Restrictive lung disease;   

Others  :  796526
DOI  :  10.1186/1465-9921-14-22

 received in 2012-11-29, accepted in 2013-02-18,  发布年份 2013

【 摘 要 】

Background

Exercise training is of benefit for patients with restrictive lung disease. However, it tends to be intolerable for those with severe disease. We examined whether providing ventilatory assistance by using negative pressure ventilators (NPV) during exercise training is feasible for such patients and the effects of training.

Methods

36 patients with restrictive lung disease were prospectively enrolled for a 12-week multidisciplinary rehabilitation program. During this program, half of them (n:18; 60.3 ± 11.6 years; 6 men; FVC: 32.5 ± 11.7% predicted ) received regular sessions of exercise training under NPV, whilst the 18 others (59.6 ± 12.3 years; 8 men; FVC: 37.7 ± 10.2% predicted) did not. Exercise capacity, pulmonary function, dyspnea and quality of life were measured. The primary endpoint was the between-group difference in change of 6 minute-walk distance (6MWD) after 12 weeks of rehabilitation.

Results

All patients in the NPV-exercise group were able to tolerate and completed the program. The between-group differences were significantly better in the NPV-exercise group in changes of 6MWD (34.1 ± 12.7 m vs. -32.5 ± 17.5 m; P = 0.011) and St George Score (−14.5 ± 3.6 vs. 11.8 ± 6.0; P < 0.01). There was an improvement in dyspnea sensation (Borg’s scale, from 1.4 ± 1.5 point to 0.8 ± 1.3 point, P = 0.049) and a small increase in FVC (from 0.85 ± 0.09 L to 0.91 ± 0.08 L, P = 0.029) in the NPV-exercise group compared to the control group.

Conclusion

Exercise training with NPV support is feasible for patients with severe restrictive lung diseases, and improves exercise capacity and health-related quality of life.

【 授权许可】

   
2013 Ho et al; licensee BioMed Central Ltd.

【 图 表 】

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