Allergic Disorders in Africa and Africans: Is It Primarily a Priority?

World Allergy Organization Journal

Jaffu Othniel Chilongola¹  Erasto Vitus Mbugi² 

[1] Kilimanjaro Clinical Research Institute, Kilimanjaro Christian Medical College, Moshi, Tanzania;Muhimbili University of Health and Allied Sciences, Biochemistry Department, School of Medicine, P.O. Box 65001, Dar es Salaam, Tanzania

关键词: Africa;    allergens;    allergy;   

Others  :  1180786
DOI  :  10.1097/WOX.0b013e3181e1976c

【 摘 要 】

In Africa, the burden of some diseases has been a problem for centuries. The spectrum of African diseases includes allergies, infections, nutritional deficiencies, and natural disasters. Efforts made by scientists to search for possible means of disease control have been outstanding; however, in some infections, solutions are still out of reach. In disease control programs, it might be worth-while to pay attention to the most striking diseases than merely follow a holistic approach. This short review tackles the problems of allergy and allergens in Africa as compared with other disease burdens that may suggest the need for a more balanced approach based on priority.

【 授权许可】

   
2010 World Allergy Organization; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Obeng BB, Hartgers F, Boakye D, Yazdanbakhsh M: Out of Africa: what can be learned from the studies of allergic disorders in Africa and Africans? Curr Opin Allergy Clin Immunol 2008, 8:391-397.
• [2]Rauter I, Krauth M-T, Westritschnig K, et al.: Mast cell-derived proteases control allergic inflammation through cleavage of IgE. J Allergy Clin Immunol 2008, 121:197-202.
• [3]Wuthrich B, Schindler C, Leuenberger P, Ackermann-Liebrich U: Prevalence of atopy and pollinosis in the adult population of Switzerland (SAPALDIA study). Swiss study on air pollution and lung diseases in adults. Int Arch Allergy Immunol 1995, 106:149.
• [4]Linneberg A: Increase in allergy: a global challenge. Drugs Today (Barc) 2008, 44(Suppl B):5-10.
• [5]Obihara CC, Marais BJ, Gie RP, et al.: The association of prolonged breastfeeding and allergic disease in poor urban children. Eur Respir J 2005, 25:970-977.
• [6]Kamradt T, Goggel R, Erb KJ: Induction, exacerbation and inhibition of allergic and autoimmune diseases by infection. Trends Immunol 2005, 26:260-267.
• [7]van den Biggelaar AHJ, Hua T-D, Rodrigues LC, Kremsner PG, Yazdanbakhsh M, Kube D: Genetic variation in IL-10 is associated with atopic reactivity in Gabonese schoolchildren. J Allergy Clin Immunol 2007, 120:973-975.
• [8]van den Biggelaar AHJ, Lopuhaa C, van Ree R, et al.: The prevalence of parasite infestation and house dust mite sensitization in Gabonese schoolchildren. Int Arch Allergy Immunol 2001, 126:231-238.
• [9]van den Biggelaar AHJ, van Ree R, Rodrigues LC, et al.: Decreased atopy in children infected with Schistosoma haematobium: a role for parasite-induced interleukin-10. Lancet 2000, 356:1723-1727.
• [10]Yazdanbakhsh M, Kremsner PG, van Ree R: Allergy, parasites, and the hygiene hypothesis. Science 2002, 296:490-494.
• [11]Yazdanbakhsh M, Matricardi PM: Parasites and the Hygiene Hypothesis. Clin Rev Allergy Immunol 2004, 26:15-23.
• [12]Yazdanbakhsh M, van den Biggelaar A, Maizels RM: Th2 responses without atopy: immunoregulation in chronic helminth infections and reduced allergic disease. Trends Immunol 2001, 22:372-377.
• [13]Ndiaye M, Bousquet J: Allergies and parasitoses in sub-Saharan Africa. Clin Rev Allergy Immunol 2004, 26:105-114.
• [14]Obihara CC, Bardin PG: Hygiene hypothesis, allergy and BCG: a dirty mix? Clin Exp Allergy 2008, 38:388-392.
• [15]Obihara CC, Beyers N, Gie RP, et al.: Respiratory atopic disease, Ascaris-immunoglobulin E and tuberculin testing in urban South African children. Clin Exp Allergy 2006, 36:640-648.
• [16]Adams JFA, Schölvinck EH, Gie RP, Potter PC, Beyers N, Beyers AD: Decline in total serum IgE after treatment for tuberculosis. Lancet 1999, 353:2030-2032.
• [17]Obihara CC, Beyers N, Gie RP, et al.: Inverse association between Mycobacterium tuberculosis infection and atopic rhinitis in children. Allergy 2005, 60:1121-1125.
• [18]Obihara CC, Bollen CW, Beyers N, Kimpen JL: Mycobacterial infection and atopy in childhood: a systematic review. Pediatr Allergy Immunol 2007, 18:551-559.
• [19]Pawankar R, Baena-Cagnani CE, Bousquet J, et al.: State of World Allergy Report 2008: allergy and chronic respiratory diseases. World Allergy Org J 2008, 1(Suppl):S4-S17.
• [20]Potter PC, Warner JO, Pawankar R, et al.: Recommendations for competency in allergy training for undergraduates qualifying as medical practitioners: a position paper of the World Allergy Organization. World Allergy Org J 2009, 2:150-154.
• [21]Zar HJ, Ehrlich RI, Workman L, Weinberg EG: The changing prevalence of asthma, allergic rhinitis and atopic eczema in African adolescents from 1995 to 2002. Pediatr Allergy Immunol 2007, 18:560-565.
• [22]Motala C: Food Allergy: World Allergy Organization. Available at: http://www.worldallergy.org/public/allergic diseases center/foodallergy/ webcite. Accessed March 25, 2010
• [23]Potter PC: Inaugural lecture: allergy in southern Africa. Curr Allergy Clin Immunol 2009, 22(4):156-161.
• [24]Madsen C: Prevalence of food allergy/intolerance in Europe. Environ Toxicol Pharmacol 1997, 4:163-167.
• [25]Veien NK, Hattel T, Laurberg G: Low nickel diet: an open prospective trial. J Am Acad Dermatol 1993, 29:1002.
• [26]Veien NK, Hattel T, Laurberg G: Can oral challenge with balsam of Peru predict possible benefit from a low-balsam diet? Am J Contact Dermat 1996, 7:84.
• [27]Mercer MJ, Joubert G, Ehrlich RI, et al.: Socioeconomic status and prevalence of allergic rhinitis and atopic eczema symptoms in young adolescents. Pediatr Allergy Immunol 2004, 15:234-241.
• [28]Thyssen JP, Johansen JD, Linneberg A, Menné T: The epidemiology of hand eczema in the general population: prevalence and main findings. Cont Dermatitis 2010, 62:75-87.
• [29]Auricchio S, Semenza G: Introduction Common Food Intolerances 2: Milk in Human Nutrition and Adult-Type Hypolactasia. Karger: Basel; 1993.
• [30]Brugman E, Meulmeester JF, Spee-van der Wekke A, Beuker RJ, Radder JJ, Verloove-Vanhorick SP: Prevalence of self-reported food hypersensitivity among school children in The Netherlands. Eur J Clin Nutr 1998, 52:577-581.
• [31]World Health Organization (WHO): Reducing Risks, Promoting Healthy Life. Geneva, Switzerland; 2002.
• [32]Breman JG: The ears of the hippopotamus: manifestations, determinants, and estimates of the malaria burden. Am J Trop Med Hyg 2001, 64:1-11.
• [33]Moore M, Ewart S: Policy challenges in malaria vaccine introduction. Am J Trop Med Hyg 2004, 71(Suppl 2):248-252.
• [34]Chaisson RE, Martinson NA: Tuberculosis in Africa: combating an HIV-driven crisis. N Eng J Med 2008, 358:11.
• [35]UNAIDS: AIDS Epidemic Update. Available at: http://www.unaids.org/en/KnowledgeCentre/HIVData/EpiUpdate/EpiUpdArc/2009 webcite
• [36]UNAIDS: Report on the Global AIDS Epidemic. Available at: http://www.unaids.org/en/KnowledgeCentre/HIVData/GlobalReport/2008/2 webcite
• [37]Estmbale BBA: Parasitic infestation in children. E Afr Med J 2001, 277-278.
• [38]Tohon ZB, Mainassara HB, Garba A, et al.: Controlling schistosomiasis: significant decrease of anaemia prevalence one year after a single dose of praziquantel in Nigerien schoolchildren. PLoS Negl Trop Dis 2008, 2:e241.
• [39]Modjarrad K, Zulu I, Redden DT, Njobvu L, Freedman DO, Vermund SH: Prevalence and predictors of intestinal helminth infections among human immunodeficiency virus type 1-infected adults in an urban African setting. Am J Trop Med Hyg 2005, 73:777-782.
• [40]Potter PC, Davis G, Manjra A, Luyt D: House dust mite allergy in Southern Africa: historical perspective and current status. Clin Exp Allergy 1996, 26:132-137.
• [41]Potter PC: Overview of the indigenous allergens of South Africa. Curr Allergy Clin Immunol 2007, 20:174-176.
• [42]van Niekerk CH, Weinberg EG, Shore SC, Heese HV, van Schalkwyk JD: Prevalence of asthma: a comparative study of urban and rural Xhosa children. Clin Exp Allergy 1979, 9:319-324.
• [43]Steinman HA, Donson H, Kawalski M, Toerien A, Potter PC: Bronchial hyper-responsiveness and atopy in urban, peri-urban and rural South African children. Pediatr Allergy Immunol 2003, 14:383-393.
• [44]ISAAC. ISAAC Steering Committee: Worldwide variation in prevalence of symptoms of asthma, allergic rhinoconjunctivitis and atopic eczema. Lancet 1998, 351:1225-1232.
• [45]Nicolaou N, Siddique N, Custovic A: Allergic disease in urban and rural populations: increasing prevalence with increasing urbanization. Allergy 2005, 60:1357-1360.
• [46]Report WHO: WHO European Centre for Environment and Health. Effects of air pollution on children's health and development: a review of the evidence. Copenhagen, WHO Regional Office for Europe. Available at: http://www.euro.who.int/document/E86575.pdf webcite. Accessed January 8, 2010
• [47]Report WHO: WHO Regional Office for Europe. Health aspects of air pollution: results from the WHO project "systematic review of health aspects of air pollution in Europe". Scherfigsvej 8, DK-2100 Copenhagen Ø, Denmark; 2004.
• [48]Marshall GD: Internal and external environmental influences in allergic diseases. J Am Osteopath Assoc 2004, 104(Suppl):S1-S6.
• [49]Weinberg EG: Urbanization and childhood asthma: an African perspective. J Allergy Clin Immunol 2000, 105:224-231.
• [50]Asmah J, Dawn LL, Siti Arija Mad A, et al.: Low prevalence of latex sensitivity in South African spina bifida children in Cape Town. Pediatr Allergy Immunol 2005, 16:165-170.
• [51]Sibanda EN: Inhalant allergies in Zimbabwe: a common problem. Int Arch Allergy Immunol 2003, 130:2-9.
• [52]SAARWG: Allergic rhinitis in South Africa: diagnosis and management. Consensus document: South African Allergic Rhinitis Working Group (SAARWG). SA Med J 1996, 86:1315-1328.
• [53]SAAS: South African Allergy Society. Available at: http://www.allergysa.org/ webcite. Accessed March 24, 2010
• [54]Gadermaier G, Dedic A, Obermeyer G, Frank S, Himly M, Ferreira F: Biology of weed pollen allergens. Curr Allergy Asthma Rep 2004, 4:391-400.
• [55]Dagoye D, Bekele Z, Woldemichael K, et al.: Wheezing, allergy, and parasite infection in children in urban and rural Ethiopia. Am J Respir Crit Care Med 2003, 167:1369-1373.
• [56]Dagoye D, Bekele Z, Woldemichael K, et al.: Domestic risk factors for wheeze in urban and rural Ethiopian children. QJM 2004, 97:489-498.
• [57]Van Niekerk CH, Weinberg EG, Shore SC, et al.: Prevalence of childhood asthma in Africa. Lancet 1977, 309:96-97.
• [58]Palyvos N, Emmanouel N, Saitanis C: Mites associated with stored products in Greece. Exp Appl Acarol 2008, 44:213-226.
• [59]Butler N: National Guidelines at a glance: allergic rhinitis. SA Pharmaceutical J 2009, 76:25-27.
• [60]Cooper PJ, Barreto ML, Rodrigues LC: Human allergy and geohelminth infections: a review of the literature and a proposed conceptual model to guide the investigation of possible causal associations. Br Med Bull 2006, 79-80:203-218.
• [61]Motala C: New perspectives in the diagnosis of food allergy. Curr Allergy Clin Immunol 2002, 15:96-100.
• [62]Matricardi PM, Rosmini F, Riondino S, et al.: Exposure to foodborne and orofecal microbes versus airborne viruses in relation to atopy and allergic asthma: epidemiological study. BMJ 2000, 320:412-417.
• [63]Matricardi PM, Rosmini F, Panetta V, Ferrigno L, Bonini S: Hay fever and asthma in relation to markers of infection in the United States. J Allergy Clin Immunol 2002, 110:381-387.
• [64]Linneberg A, Østergaard C, Tvede M, et al.: IgG antibodies against microorganisms and atopic disease in Danish adults: the Copenhagen Allergy Study. J Allergy Clin Immunol 2003, 111:847-853.
• [65]Araujo MI, de Carvalho EM: Human schistosomiasis decreases immune responses to allergens and clinical manifestations of asthma. Chem Immunol Allergy 2006, 90:29-44.
• [66]Carvalho EM, Bastos LS, Araujo MI: Worms and allergy. Parasite Immunol 2006, 28:525-534.
• [67]Cardoso LS, Oliveira SC, Góes AM, et al.: Schistosoma mansoni antigens modulate the allergic response in a murine model of ovalbumininduced airway inflammation. Clin Exp Immunol 2010, in press.
• [68]Araujo MI, Lopes AA, Medeiros M, et al.: Inverse association between skin response to aeroallergens and Schistosoma mansoni infection. Int Arch Allergy Immunol 2000, 123:145-148.
• [69]Cooper PJ, Chico ME, Rodrigues LC, et al.: Reduced risk of atopy among school-age children infected with geohelminth parasites in a rural area of the tropics. J Allergy Clin Immunol 2003, 111(Suppl 1):995-1000.
• [70]Lynch NR, Lopez RI, Di Prisco-Fuenmayor MC, et al.: Allergic reactivity and socio-economic level in a tropical environment. Clin Allergy 1987, 17:199-207.
• [71]Lynch NR, Hagel I, Perez M, Di Prisco MC, Lopez R, Alvarez N: Effect of anthelmintic treatment on the allergic reactivity of children in a tropical slum. J Allergy Clin Immunol 1993, 92:404-411.
• [72]Scrivener S, Yemaneberhan H, Zebenigus M, et al.: Independent effects of intestinal parasite infection and domestic allergen exposure on risk of wheeze in Ethiopia: a nested case-control study. Lancet 2001, 358:1493-1499.
• [73]Nyan OA, Walraven GEL, Banya WAS, et al.: Atopy, intestinal helminth infection and total serum IgE in rural and urban adult Gambian communities. Clin Exp Allergy 2001, 31:1672-1678.
• [74]Cooper PJ: Interactions between helminth parasites and allergy. Curr Opin Allergy Clin Immunol 2009, 9:29-37.
• [75]van der Kleij D, Latz E, Brouwers JFHM, et al.: A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization. J Biol Chem 2002, 277:48122-48129.
• [76]Okano M, Satoskar AR, Nishizaki K, Harn DA Jr: Lacto-N-fucopentaose III found on schitosoma mansoni egg antigens functions as adjuvant for proteins by inducing Th2-type response. J Immunol 2001, 167:442-450.
• [77]Pacifico LGG, Marinho FAV, Fonseca CT, et al.: Schistosoma mansoni antigens modulate experimental allergic asthma in a murine model: a major role for CD4+ CD25+ Foxp3+ T cells independent of interleukin-10. Infect Immun 2009, 77:98-107.
• [78]Platts-Mills TAE, Cooper PJ: Differences in asthma between rural and urban communities in South Africa and other developing countries. J Allergy Clin Immunol 2010, 125:106-107.
• [79]Cullinan P: Asthma in African cities. Thorax 1998, 53:909-910.
• [80]Grant AV, Araujo MI, Ponte EV, et al.: High heritability but uncertain mode of inheritance for total serum IgE level and schistosoma mansoni infection intensity in a Schistosomiasis-endemic Brazilian population. J Infect Dis 2008, 198:1227-1236.
• [81]Vergara C, Tsai YJ, Grant AV, et al.: Gene encoding Duffy antigen/receptor for chemokines is associated with asthma and IgE in three populations. Am J Respir Crit Care Med 2008, 178:1017-1022.
• [82]Gao P-S, Shimizu K, Grant AV, et al.: Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma. Eur J Hum Genet 2010, in press.
• [83]Du Toit G, Katz Y, Sasieni P, et al.: Early consumption of peanuts in infancy is associated with a low prevalence of peanut allergy. J Allergy Clin Immunol 2008, 122:984-991.
• [84]Jeebhay MF: Occupational allergy and asthma among food processing workers in South Africa. African Newsletter 2002, 12:59-62.
• [85]Jeebhay MF, Robins TG, Lehrer SB, Lopata AL: Occupational seafood allergy: a review. Occup Environ Med 2001, 58:553-562.
• [86]Lopata AL, Jeebhay MF: Allergy and asthma to indigenous seafood species in South Africa. Curr Allergy Clin Immunol 2007, 20:196-200.
• [87]Sibanda EN: Research and clinical aspects of immunology in Africa. Curr Opin Immunol 2001, 13:528-532.
• [88]Riedler J, Braun-Fahrländer C, Eder W, et al.: Exposure to farming in early life and development of asthma and allergy: a cross-sectional survey. Lancet 2001, 358:1129-1133.
• [89]Jeannin P, Lecoanet S, Delneste Y, Gauchat J-F, Bonnefoy J-Y: IgE versus IgG4 production can be differentially regulated by IL-10. J Immunol 1998, 160:3555-3561.
• [90]Obihara CC: Infection and atopic disease burden in African countries: key to solving the 'hygiene hypothesis'? Curr Allergy Clin Immunol 2007, 20:178-183.
• [91]Westritschnig K, Sibanda E, Thomas W, et al.: Analysis of the sensitization profile towards allergens in central Africa. Clin Exp Allergy 2003, 33:22-27.