Stereotactic radiosurgery alone for small cell lung cancer: a neurocognitivebenefit?

Radiation Oncology

Charles B Simone II¹  Michelle Alonso-Basanta¹  Eric Ojerholm¹ 

[1] Department of Radiation Oncology, University of Pennsylvania, 3400 CivicCenter Boulevard, PCAM-2 West, Philadelphia, PA 19104, USA

关键词: Prophylactic cranial irradiation;    Neurocognitive;    Whole-brain radiation therapy;    Stereotactic radiosurgery;    Small cell lung cancer;   

Others  :  1228550
DOI  :  10.1186/1748-717X-9-218

 received in 2014-08-29, accepted in 2014-09-14,  发布年份 2014

【 摘 要 】

Yomo and Hayashi reported results of stereotactic radiosurgery alone for brain metastases from small cell lung cancer. This strategy aims to avoid the neurocognitive effects of whole-brain radiation therapy. However, radiosurgery alone increases the risk of distant intracranial relapse, which can independently worsen cognition. This concern is heightened in histologies like small cell with high predilection for intracranial spread. The majority of study patients developed new brain disease, suggesting radiosurgery alone may not be an optimal strategy for preserving neurocognitive function in this population. We suggest whole-brain radiation therapy should remain the standard of care for small cell lung cancer.

【 授权许可】

   
2014 Ojerholm et al.; licensee BioMed Central Ltd.

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