Phosphorus ingestion improves oral glucose tolerance of healthy male subjects: a crossover experiment

Nutrition Journal

Omar Obeid²  Sani Hlais¹  Hala Ghattas²  Christelle Abi-Rashed²  May Khattab² 

[1] Department of Family Medicine, American University of Beirut, Beirut, Lebanon;Department of Nutrition and Food Sciences, American University of Beirut, Beirut, Lebanon

关键词: Insulin sensitivity;    OGTT;    Area under the curve;    Glucose;    Phosphorus;   

Others  :  1230017
DOI  :  10.1186/s12937-015-0101-5

 received in 2015-05-06, accepted in 2015-10-12,  发布年份 2015

【 摘 要 】

Background

Fasting serum phosphorus (P) was reported to be inversely related to serum glucose and insulin, while the impact of P ingestion is not well documented. The effect of P intake with or before glucose ingestion on postprandial glucose and insulin statuses was investigated.

Method

Two cross over experiments using healthy male subjects were conducted. Experiment 1: Overnight fasted subjects (n = 7) randomly received: 500 mg of P tablets, glucose (75 g) solution with placebo or 500 mg of P tablets. Experiment 2: Overnight fasted subjects (n = 8) underwent similar procedures to those of experiment 1, except that placebo or 500 mg P tablets were given 60 min prior to glucose ingestion.

Results

In both experiments, serum P decreased following glucose ingestion. Co-ingestion of P with glucose improved, at time 60 min, postprandial glucose (P < 0.05), insulin (P < 0.05), and insulin sensitivity index (p < 0.006), while P pre-ingestion failed to exert similar effect.

Conclusion

This study suggests that postprandial glucose and insulin are affected by exogenous P supply, especially when co-ingested with glucose.

【 授权许可】

   
2015 Khattab et al.

【 图 表 】

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