Impact of one-hour postchallenge glucose on the relationship between insulin sensitivity and secretion

Endocrine Journal

Toru Aizawa²  Masafumi Katakura³  Yasuto Nakasone²  Yuka Sato²  Rie Oka¹  Keishi Yamauchi² 

[1] Department of Internal Medicine, Hokuriku Central Hospital, Toyama 932-8503, Japan;Diabetes Center, Aizawa Hospital, Matsumoto 390-8510, Japan;Department of Medicine, Chikuma Central Hospital, Chikuma 387-0011, Japan

关键词: Insulin sensitivity;    Insulin secretion;    OGTT;    Postchallenge glucose;   

DOI  :  10.1507/endocrj.EJ15-0122

学科分类：内分泌与代谢学

来源: Japan Endocrine Society

【 摘 要 】

References(35)Cited-By(2)The impact of postchallenge glucose on the relationship between insulin sensitivity (SI) and secretion (β) is unknown. We analyzed data from 2,264 health examinees (male/female 1,524/740, median age 54 yrs) with normal glucose tolerance (NGT, n = 1,623), non-diabetic hyperglycemia (NDH, n = 555), or diabetes (DM, n = 86) using OGTT-derived indices of SI (insulin sensitivity index [ISI]-Matsuda, 1/HOMA-IR, and 1/fasting IRI) and β (δIRI0-30/δPG0-30, and Stumvoll 1st [Stumvoll-1] and 2nd [Stumvoll-2] phases).The combination of 1/HOMA-IR and Stumvoll-1 recapitulated the hyperbolic SI-β relationship with the slope of the fitted line -1.000 in NGT subjects, and therefore it was utilized in the following analysis of the SI-β correlation.In multiple regression analysis of the relationship between SI and β, an independent correlation was found for 1 h-plasma glucose (PG; PG60) but not for 2 h-PG.When the NGT subjects were grouped by PG60 quartile (Q), the fitted line was flat in Q1 but progressively steeper from Q2 to Q4, with a slope (95%CI) of -0.663 (-0.726~-0.605), -0.680 (-0.745~-0.622), -0.847 (-0.922~-0.779), and -1.259 (-1.370~-1.158) (P for trend P 60 Q for NGT, NDH, and DM.In conclusion, using the 1/HOMA-IR-Stumvoll-1 pair for an analysis of the SI-β relationship, elevated PG60 was associated with steepening and downward shifting of the fitted line for the SI-β correlation.The finding suggests impaired beta cell function.

【 授权许可】

Unknown