Diverse origins of hepatitis C virus in HIV co-infected men who have sex with men in Hong Kong

Virology Journal

Shui Shan Lee¹  Ngai Sze Wong¹  Ka Hing Wong²  Ada W. Lin²  Denise P. Chan¹ 

[1] Stanley Ho Centre for Emerging Infectious Diseases, The Chinese University of Hong Kong, Hong Kong, China;Centre for Health Protection, Department of Health, Hong Kong, China

关键词: Sexual transmission;    Men who have sex with men;    HIV;    Acute HCV infection;   

Others  :  1224528
DOI  :  10.1186/s12985-015-0355-8

 received in 2015-02-03, accepted in 2015-07-30,  发布年份 2015

【 摘 要 】

Background

Worldwide, Hepatitis C (HCV) infection has been increasingly recognized in HIV-positive men who have sex with men (MSM). The objective of this study was to characterize the transmission dynamics of acute HCV infection in HIV-positive MSM in Hong Kong using a molecular approach.

Findings

We retrospectively examined 24 HIV-positive MSM with acute HCV infection diagnosed between 2009 and 2014 in Hong Kong. Detection and molecular characterization of HCV was successfully performed in 22 (91.7 %) patients. Genotype 3a was the most prevalent as identified in 14 (63.6 %) MSM, followed by 1a in 4 (18.2 %), 6a in 2 (9.1 %), and 1each (4.5 %) for 1b and 2a. The high prevalence of genotype 3a in MSM was in stark contrast to its rarity among HCV infected injection drug users (IDU) in Hong Kong. Phylogenetic analyses revealed a monophyletic HCV-3a cluster composing of MSM without injection history, and a homologous pair with HCV-6a genotype. There was otherwise no temporal or genetic clustering of the corresponding HIV sequences.

Conclusions

The origin of sexually acquired acute HCV infections in HIV-positive MSM was diverse and not directly linked with local IDU. The transmission dynamics of HIV and HCV infections in MSM in Hong Kong were evidently unrelated.

【 授权许可】

   
2015 Chan et al.

【 图 表 】

Fig. 1.

Fig. 2.

Fig. 3.

【 参考文献 】

• [1]Browne R, Asboe D, Gilleece Y, Atkins M, Mandalia S, Gazzard B et al.. Increased numbers of acute hepatitis C infections in HIV positive homosexual men; is sexual transmission feeding the increase? Sex Transm Infect. 2004; 80:326-7.
• [2]Luetkemeyer A, Hare CB, Stansell J, Tien PC, Charlesbois E, Lum P et al.. Clinical presentation and course of acute hepatitis C infection in HIV-infected patients. J Acquir Immune Defic Syndr. 2006; 41:31-6.
• [3]Matthews GV, Hellard M, Kaldor J, Lloyd A, Dore GJ. Further evidence of HCV sexual transmission among HIV-positive men who have sex with men: response to Danta et al. AIDS. 2007; 21:2112-3.
• [4]Su YC, Liu WC, Chang LH, Wu PY, Luo YZ, Wu CH et al.. Incidence of recent HCV infection among persons seeking voluntary counselling and testing for HIV and sexually transmitted infections in Taiwan. J Int AIDS Soc. 2014; 17(4 Suppl 3):19640.
• [5]van de Laar TJ, Matthews GV, Prins M, Danta M. Acute hepatitis C in HIV-infected men who have sex with men: an emerging sexually transmitted infection. AIDS. 2010; 24:1799-812.
• [6]van der Helm JJ, Prins M, del Amo J, Bucher HC, Chene G, Dorrucci M et al.. The hepatitis C epidemic among HIV-positive MSM: incidence estimates from 1990 to 2007. AIDS. 2011; 25:1083-91.
• [7]Wong NS, Chan PC, Lee SS, Lee SL, Lee CK. A multilevel approach for assessing the variability of hepatitis C prevalence in injection drug users by their gathering places. Int J Infect Dis. 2013; 17:e193-8.
• [8]Chan DP, Lee SS, Lee KC. The effects of widespread methadone treatment on the molecular epidemiology of hepatitis C virus infection among injection drug users in Hong Kong. J Med Virol. 2011; 83:1187-94.
• [9]Chen JH, Wong KH, Li PC, Chan KK, Lee MP, To SW et al.. In-house human immunodeficiency virus-1 genotype resistance testing to determine highly active antiretroviral therapy resistance mutations in Hong Kong. Hong Kong Med J. 2012; 18:20-4.
• [10]Matthews GV, Pham ST, Hellard M, Grebely J, Zhang L, Oon A et al.. Patterns and characteristics of hepatitis C transmission clusters among HIV-positive and HIV-negative individuals in the Australian trial in acute hepatitis C. Clin Infect Dis. 2011; 52:803-11.
• [11]Gower E, Estes C, Blach S, Razavi-Shearer K, Razavi H. Global epidemiology and genotype distribution of the hepatitis C virus infection. J Hepatol. 2014; 61:S45-57.
• [12]Meng Z, Xin R, Zhong P, Zhang C, Abubakar YF, Li J et al.. A new migration map of HIV-1 CRF07_BC in China: analysis of sequences from 12 provinces over a decade. PLoS One. 2012; 7: Article ID e52373
• [13]van de Laar T, Pybus O, Bruisten S, Brown D, Nelson M, Bhagani S et al.. Evidence of a large, international network of HCV transmission in HIV-positive men who have sex with men. Gastroenterology. 2009; 136:1609-17.