Modulation of obesity-induced inflammation by dietary fats: mechanisms and clinical evidence

Nutrition Journal

Kalanithi Nesaretnam³  Lin Faun Chang²  Chee-Yan Chang¹  Kim-Tiu Teng³ 

[1] Department of Molecular Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia;Department of Medicine, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia;Product Development and Advisory Services, Malaysian Palm Oil Board (MPOB), 6 Persiaran Institusi, Bandar Baru Bangi, 43000 Kajang, Selangor, Malaysia

关键词: Adipose tissue;    Polyunsaturated fatty acids;    Saturated fatty acids;    Dietary fats;    Obesity;    Inflammation;   

Others  :  801816
DOI  :  10.1186/1475-2891-13-12

 received in 2013-04-12, accepted in 2014-01-13,  发布年份 2014

【 摘 要 】

Obesity plays a pivotal role in the development of low-grade inflammation. Dietary fatty acids are important modulators of inflammatory responses. Saturated fatty acids (SFA) and n-6 polyunsaturated fatty acids (PUFA) have been reported to exert pro-inflammatory effects. n-3 PUFA in particular, possess anti-inflammatory properties. Numerous clinical studies have been conducted over decades to investigate the impact of dietary fatty acids on inflammatory response in obese individuals, however the findings remained uncertain. High fat meals have been reported to increase pro-inflammatory responses, however there is limited evidence to support the role of individual dietary fatty acids in a postprandial state. Evidence in chronic studies is contradictory, the effects of individual dietary fatty acids deserves further attention. Weight loss rather than n-3 PUFA supplementation may play a more prominent role in alleviating low grade inflammation. In this context, the present review provides an update on the mechanistic insight and the influence of dietary fats on low grade inflammation, based on clinical evidence from acute and chronic clinical studies in obese and overweight individuals.

【 授权许可】

   
2014 Teng et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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