Informed consent in the psychosis prodrome: ethical, procedural and cultural considerations

Philosophy, Ethics, and Humanities in Medicine

Robert K Heinssen²  Sarah E Morris¹ 

[1]Division of Adult Translational Research, National Institute of Mental Health, 6001 Executive Blvd, North Bethesda, MD 20892, USA

[2]Division of Services and Intervention Research, National Institute of Mental Health, 6001 Executive Blvd, North Bethesda, MD 20892, USA

关键词: Culture;    International;    Schizophrenia;    Psychosis;    Prodrome;    Informed consent;    Ethics;   

Others  :  1132042
DOI  :  10.1186/1747-5341-9-19

 received in 2014-02-03, accepted in 2014-10-24,  发布年份 2014

【 摘 要 】

Research focused on the prodromal period prior to the onset of psychosis is essential for the further development of strategies for early detection, early intervention, and disease pre-emption. Such efforts necessarily require the enrollment of individuals who are at risk of psychosis but have not yet developed a psychotic illness into research and treatment protocols. This work is becoming increasingly internationalized, which warrants special consideration of cultural differences in conceptualization of mental illness and international differences in health care practices and rights regarding research participation. The process of identifying and requesting informed consent from individuals at elevated risk for psychosis requires thoughtful communication about illness risk and often involves the participation of family members. Empirical studies of risk reasoning and decisional capacity in young people and individuals with psychosis suggest that most individuals who are at-risk for psychosis can adequately provide informed consent; however ongoing improvements to tools and procedures are important to ensure that this work proceeds with maximal consideration of relevant ethical issues. This review provides a discussion of these issues in the context of international research efforts.

【 授权许可】

   
2014 Morris and Heinssen; licensee BioMed Central Ltd.

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