Clinical and inheritance profiles of Kallmann syndrome in Jordan

Reproductive Health

Kamel M Ajlouni¹  Nadima S Shegem¹  Nadim S Jarrah¹  Hanan A Hamamy¹  Mousa A AbuJbara¹ 

[1] The National Center for Diabetes, Endocrinology and Genetics, Amman, Jordan

关键词: Jordan;    Microphallus;    Hypogonadotropic hypogonadism;    Kallmann syndrome;   

Others  :  1146756
DOI  :  10.1186/1742-4755-1-5

 received in 2004-07-05, accepted in 2004-10-24,  发布年份 2004

【 摘 要 】

Background

Proper management of patients with Kallmann syndrome (KS) allows them to attain a normal reproductive health. The purpose of this study is to demonstrate the presentation modalities, phenotypes and the modes of inheritance among 32 patients with Kallmann syndrome in Jordan. Recognition of the syndrome allows for prompt proper management and provision of genetic counselling.

Subjects

Over a period of five years (1999–2004), the clinical and inheritance profiles of 26 male and 6 female patients with Kallmann syndrome from 12 families were evaluated at the National Center for Diabetes, Endocrinology and Genetics in Jordan.

Results

The patients belonged to twelve Jordanian and Palestinian families and their age at presentation ranged from 4 – 46 years. Nine boys aged 4–14 years presented with cryptorchidism and microphallus, all other males presented with delayed puberty, hypogonadism and/or infertility. The main presentation among six female patients was primary amenorrhea. Intrafamilial variability in clinical phenotype was specifically evident for renal abnormalities and sensorineural hearing impairment. Familial KS was diagnosed in 27 patients belonging to five families with the X-linked mode of inheritance and two families with the autosomal recessive mode of inheritance.

Conclusions

(1) the majority of cases in this study represented the X-linked form of KS, which might point to a high prevalence of Kal 1 gene in the population. (2) Genetic counselling helps these families to reach a diagnosis at an early age and to decide about their reproductive options. (3) Children presenting with cryptorchidism and microphallus in our population should be investigated for KS.

【 授权许可】

   
2004 AbuJbara et al; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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