Intracytoplasmic morphologically selected sperm injection versus conventional intracytoplasmic sperm injection: a randomized controlled trial

Reproductive Biology and Endocrinology

Stefano Palomba¹  Maria Teresa Villani¹  Barbara Valli¹  Daria Morini¹  Ilaria Rondini¹  Angela Falbo¹  Eleonora Fornaciari¹  Alessia Nicoli¹  Giovanni Battista La Sala² 

[1] Obstetrics and Gynecology Unit, Arcispedale S. Maria Nuova of Reggio Emilia, IRCCS, Reggio Emilia, Viale Risorgimento 80, Reggio Emilia, 42123, Italy;University of Modena and Reggio Emilia, Via del Pozzo, 71, Modena, 41124, Italy

关键词: RCT;    MSOME;    IMSI;    Intracytoplasmic morphologically selected sperm injection;    ICSI;    Intracytoplasmic sperm injection;   

Others  :  1224968
DOI  :  10.1186/s12958-015-0096-y

 received in 2015-06-25, accepted in 2015-08-20,  发布年份 2015

【 摘 要 】

Background

Intracytoplasmic morphologically selected sperm injection (IMSI) is still proposed and employed in the clinical practice to improve the reproductive outcome in infertile couples scheduled for conventional intracytoplasmic sperm injection (cICSI). The aim of the current randomized controlled trial (RCT) was to test the hypothesis that IMSI gives a better live birth delivery rate than cICSI.

Methods

Infertile couples scheduled for their first cICSI cycle for male factor were allocated using a simple randomization procedure. All available biological and clinical data were recorded and analyzed in a triple-blind fashion.

Results

Our final analysis involved the first 121 patients (48 and 73 subjects for IMSI and cICSI arm, respectively) because the trial was stopped prematurely on the advice of the data safety and monitoring Committee because of concerns about IMSI efficacy at the first interim analysis. No significant difference between arms was detected in rates of clinical pregnancy per embryo transferred [11/34 (32.3 %) vs. 15/64 (23.4 %); odds ratio (OR) 1.56, 95 % (confidence interval) CI 0.62–3.93, P = 0.343] and of live birth delivery [9/48 (18.8 %) vs. 11/73 (15.1 %); OR 1.30, 95%CI 0.49–3.42, P = 0.594).

Conclusion

Current data did not support the routine use of IMSI in the clinical practice for improving cICSI results in unselected infertile couples with male factor.

【 授权许可】

   
2015 La Sala et al.

【 图 表 】

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