期刊论文详细信息
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Higher mortality rates among the elderly with mild traumatic brain injury: a nationwide cohort study
Yung-Cheng Su2  Ching-Chih Lee1  Chen-Yang Hsu3  Yi-Kung Lee2  Hsin-Yi Lin2  Po-Liang Cheng2 
[1] Cancer Center, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan;School of Medicine, Tzu Chi University, Hualien, Taiwan;Department of Public Heath, National Taiwan University, Taipei, Taiwan
关键词: Traumatic brain injury;    Mortality;   
Others  :  810400
DOI  :  10.1186/1757-7241-22-7
 received in 2013-10-13, accepted in 2014-01-25,  发布年份 2014
PDF
【 摘 要 】

Background

It is known that the risk of death in elderly patients with moderate to severe traumatic brain injury is increased. However, the relationship between mild traumatic brain injury and death has never been established. We investigated the mortality rates of older patients with mild traumatic brain injury in Taiwan to evaluate if there is a higher risk of death compared with the general population.

Methods

We utilized a sampled National Health Insurance claims database containing one million beneficiaries. We followed all adult beneficiaries older than 65 years from January 1, 2005 till December 31, 2009 to see if they died. We further identified patients with mild traumatic brain injury and compared their risk of death with the general population.

Results

We identified 5997 patients with mild traumatic brain injury and 84,117 patients without mild traumatic brain injury. After controlling for age, gender, urbanization level, socioeconomic status, diabetes, hypertension, history of alcohol intoxication, history of ischemic stroke, history of intracranial hemorrhage, malignancies, dementia and Charlson Comorbidity Index score, the adjusted hazard ratio was 1.25 (95% confidence interval, 1.16—1.34).

Conclusions

Mild traumatic brain injury is an independent significant risk factor for death in the elderly.

【 授权许可】

   
2014 Cheng et al.; licensee BioMed Central Ltd.

【 预 览 】
附件列表
Files Size Format View
20140709041827176.pdf 503KB PDF download
Figure 3. 58KB Image download
Figure 2. 59KB Image download
Figure 1. 60KB Image download
【 图 表 】

Figure 1.

Figure 2.

Figure 3.

【 参考文献 】
  • [1]Centers for Disease Control and Prevention (CDC): CDC grand rounds: reducing severe traumatic brain injury in the united states. MMWR Morb Mortal Wkly Rep 2013, 62:549-552.
  • [2]Hukkelhoven CW, Steyerberg EW, Rampen AJ, Farace E, Habbema JD, Marshall LF, Murray GD, Maas AI: Patient age and outcome following severe traumatic brain injury: an analysis of 5600 patients. J Neurosurg 2003, 99:666-673.
  • [3]Selassie AW, Cao Y, Church EC, Saunders LL, Krause J: Accelerated death rate in population-based cohort of persons with traumatic brain injury. J Head Trauma Rehabil 2013. [Epub ahead of print]
  • [4]McIntyre A, Mehta S, Aubut J, Dijkers M, Teasell RW: Mortality among older adults after a traumatic brain injury: a meta-analysis. Brain Inj 2013, 27:31-40.
  • [5]Brooks JC, Strauss DJ, Shavelle RM, Paculdo DR, Hammond FM, Harrison-Felix CL: Long-term disability and survival in traumatic brain injury: results from the national institute on disability and rehabilitation research model systems. Arch Phys Med Rehabil 2013, 94:2203-2209.
  • [6]Chou YC, Yeh CC, Hu CJ, Meng NH, Chiu WT, Chou WH, Chen TL, Liao CC: Risk and mortality of traumatic brain injury in stroke patients: two nationwide cohort studies. J Head Trauma Rehabil 2013. [Epub ahead of print]
  • [7]Gaetani P, Revay M, Sciacca S, Pessina F, Aimar E, Levi D, Morenghi E: Traumatic brain injury in the elderly: considerations in a series of 103 patients older than 70. J Neurosurg Sci 2012, 56:231-237.
  • [8]Harrison-Felix C, Kolakowsky-Hayner SA, Hammond FM, Wang R, Englander J, Dams-O’Connor K, Kreider SE, Novack TA, Diaz-Arrastia R: Mortality after surviving traumatic brain injury: risks based on age groups. J Head Trauma Rehabil 2012, 27:E45-56.
  • [9]Brown AW, Leibson CL, Mandrekar J, Ransom JE, Malec JF: Long-term survival after traumatic brain injury: a population-based analysis controlled for nonhead trauma. J Head Trauma Rehabil 2013, 29:E1-8.
  • [10]Lee YK, Lee CC, Chen CC, Wong CH, Su YC: High risk of 'failure' among emergency physicians compared with other specialists: a nationwide cohort study. Emerg Med J 2013, 30:620-622.
  • [11]National Health Insurance Database Registry: National health insurance database registry. Available: [http://w3.nhri.org.tw/nhird/en/index.htm webcite]
  • [12]Bazarian JJ, Veazie P, Mookerjee S, Lerner EB: Accuracy of mild traumatic brain injury case ascertainment using ICD-9 codes. Acad Emerg Med 2006, 13:31-38.
  • [13]Lee YK, Hou SW, Lee CC, Hsu CY, Huang YS, Su YC: Increased risk of dementia in patients with mild traumatic brain injury: a nationwide cohort study. PLoS One 2013, 8:e62422.
  • [14]Chang CM, Su YC, Lai NS, Huang KY, Chien SH, Chang YH, Lian WC, Hsu TW, Lee CC: The combined effect of individual and neighborhood socioeconomic status on cancer survival rates. PLoS One 2012, 7:e44325.
  • [15]Charlson ME, Pompei P, Ales KL, MacKenzie CR: A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis 1987, 40:373-383.
  • [16]Deyo RA, Cherkin DC, Ciol MA: Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases. J Clin Epidemiol 1992, 45:613-619.
  • [17]Schneeweiss S: Sensitivity analysis and external adjustment for unmeasured confounders in epidemiologic database studies of therapeutics. Pharmacoepidemiol Drug Saf 2006, 15:291-303.
  • [18]Hou SW, Lee YK, Hsu CY, Lee CC, Su YC: Increased risk of acute pancreatitis in patients with chronic hemodialysis: a 4-year follow-up study. PLoS One 2013, 8:e71801.
  • [19]Gradisek P, Osredkar J, Korsic M, Kremzar B: Multiple indicators model of long-term mortality in traumatic brain injury. Brain Inj 2012, 26:1472-1481.
  • [20]Thompson HJ, McCormick WC, Kagan SH: Traumatic brain injury in older adults: epidemiology, outcomes, and future implications. J Am Geriatr Soc 2006, 54:1590-1595.
  • [21]Thompson HJ, Bourbonniere M: Traumatic injury in the older adult from head to toe. Crit Care Nurs Clin North Am 2006, 18:419-431.
  • [22]Tepas JJ 3rd, Pracht EE, Orban BL, Flint LM: Insurance status, not race, is a determinant of outcomes from vehicular injury. J Am Coll Surg 2011, 212:722-727. discussion 727–729
  文献评价指标  
  下载次数:28次 浏览次数:3次