Tangential volumetric modulated arc therapy technique for left-sided breast cancer radiotherapy

Radiation Oncology

Jan Seppälä¹  Tapani Lahtinen¹  Kristiina Koskela¹  Kimmo Myllyoja¹  Janne Heikkilä¹  Tuomas Virén¹ 

[1] Cancer Center, Kuopio University Hospital, Kuopio, FI-70029, Finland

关键词: Low dose volume;    IMRT;    VMAT;    Breast cancer;    Radiotherapy;   

Others  :  1177396
DOI  :  10.1186/s13014-015-0392-x

 received in 2014-12-24, accepted in 2015-03-25,  发布年份 2015

【 摘 要 】

Background

The aim of the present study was to introduce a new restricted tangential volumetric modulated arc therapy (tVMAT) technique for whole breast irradiation and compare its dosimetric properties to other currently used breast cancer radiotherapy techniques.

Method

Ten consecutive women with left-sided breast cancer were enrolled in this retrospective study. Four treatment plans were generated for each patient: 1) standard tangential field-in-field (FinF), 2) tangential intensity modulated radiotherapy (tIMRT), 3) tangential VMAT (tVMAT) with two dual arcs of 50-60° and 4) continuous VMAT (cVMAT) with a dual arc of 240°. The plans were created with Monaco® (tIMRT, tVMAT and cVMAT) and Oncentra® (FinF) treatment planning systems.

Results

With both VMAT techniques significantly higher cardiac avoidance, dose coverage and dose homogenity were achieved when compared with FinF or tIMRT techniques (p < 0.01). VMAT techniques also decreased the high dose areas (above 20 Gy) of ipsilateral lung. There were no significant differences in the mean dose of contralateral breast between the tVMAT, tIMRT and FinF techniques. The dose coverage (V47.5 Gy) was greatest with cVMAT. However, with cVMAT the increase of contralateral breast dose was significant.

Conclusions

The present results support the hypothesis that the introduced tVMAT technique is feasible for treatment of left-sided breast cancer. With tVMAT dose to heart and ipsilateral lung can be reduced and the dose homogeneity can be improved without increasing the dose to contralateral breast or lung.

【 授权许可】

   
2015 Virén et al.; licensee BioMed Central.

【 图 表 】

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