Hypofractionated image-guided breath-hold SABR (Stereotactic Ablative Body Radiotherapy) of liver metastases – clinical results

Radiation Oncology

Frank Lohr⁴  Frederik Wenz⁴  Ralf-Dieter Hofheinz³  Frank Schneider⁴  Martine Ottstadt⁴  Ulrike Attenberger⁵  Kerstin Siebenlist⁴  Anian Frauenfeld⁴  Christel Weiss¹  Dietmar Dinter⁵  Judit Boda-Heggemann² 

[1] Department of Biomathematics and Medical Statistics, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany;Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany;III. Department of Internal Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany;Department of Radiation Oncology, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany;Institute of Diagnostic Radiology and Nuclear Medicine, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany

关键词: Toxicity;    Survival;    Local control;    Liver metastases;    Hypofractionated image-guided breath-hold SABR;   

Others  :  1160824
DOI  :  10.1186/1748-717X-7-92

 received in 2012-01-09, accepted in 2012-06-18,  发布年份 2012

【 摘 要 】

Purpose

Stereotactic Ablative Body Radiotherapy (SABR) is a non-invasive therapy option for inoperable liver oligometastases. Outcome and toxicity were retrospectively evaluated in a single-institution patient cohort who had undergone ultrasound-guided breath-hold SABR.

Patients and methods

19 patients with liver metastases of various primary tumors consecutively treated with SABR (image-guidance with stereotactic ultrasound in combination with computer-controlled breath-hold) were analysed regarding overall-survival (OS), progression-free-survival (PFS), progression pattern, local control (LC), acute and late toxicity.

Results

PTV (planning target volume)-size was 108 ± 109cm³ (median 67.4 cm³). BED2 (Biologically effective dose in 2 Gy fraction) was 83.3 ± 26.2 Gy (median 78 Gy). Median follow-up and median OS were 12 months. Actuarial 2-year-OS-rate was 31%. Median PFS was 4 months, actuarial 1-year-PFS-rate was 20%. Site of first progression was predominantly distant. Regression of irradiated lesions was observed in 84% (median time to detection of regression was 2 months). Actuarial 6-month-LC-rate was 92%, 1- and 2-years-LC-rate 57%, respectively. BED2 influenced LC. When a cut-off of BED2 = 78 Gy was used, the higher BED2 values resulted in improved local control with a statistical trend to significance (p = 0.0999). Larger PTV-sizes, inversely correlated with applied dose, resulted in lower local control, also with a trend to significance (p-value = 0.08) when a volume cut-off of 67 cm³ was used.

No local relapse was observed at PTV-sizes < 67 cm³ and BED2 > 78 Gy. No acute clinical toxicity > °2 was observed. Late toxicity was also ≤ °2 with the exception of one gastrointestinal bleeding-episode 1 year post-SABR. A statistically significant elevation in the acute phase was observed for alkaline-phosphatase; in the chronic phase for alkaline-phosphatase, bilirubine, cholinesterase and C-reactive protein.

Conclusions

A trend to statistically significant correlation of local progression was observed for BED2 and PTV-size. Dose-levels BED2 > 78 Gy cannot be reached in large lesions constituting a significant fraction of this series. Image-guided SABR (igSABR) is therefore an effective non-invasive treatment modality with low toxicity in patients with small inoperable liver metastases.

【 授权许可】

   
2012 Boda-Heggemann et al.;licensee BioMed Central Ltd.

【 图 表 】

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