会议论文详细信息
Micro-Mini & Nano-Dosimetry & Innovative Technologies in Radiation Therapy
On the dose to a moving target in stereotactic ablative body radiotherapy to lung tumors
Feygelman, V.^1 ; Dilling, T.J.^1 ; Moros, E.G.^1 ; Zhang, G.G.^1
H. Lee Moffitt Cancer Center, Tampa
FL
33612, United States^1
关键词: Density scaling;    Dose calculation;    Local control;    Moving targets;    Second orders;    Static approximations;    Targeting accuracy;    Tumor control probability;   
Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/777/1/012027/pdf
DOI  :  10.1088/1742-6596/777/1/012027
来源: IOP
PDF
【 摘 要 】

This review summarizes the hierarchy of potential dose inaccuracies in lung SABR in terms of their expected clinical impact. The two main terms are targeting accuracy and adequacy of the dose calculation algorithm. One can associate dose-errors at the 50-100% (zero order) and 10-20% (first order) levels with the former and the latter, respectively. At the first order level, strong evidence exists that using dose algorithms which do not account for 3D density scaling is associated with diminished local control. On the other hand, the second-order target dose-errors due to either static approximations to full 4D calculations, or interplay during modulated delivery, are rather unlikely to rise above 5% (conservatively, ≤ 1% tumor control probability change).

【 预 览 】
附件列表
Files Size Format View
On the dose to a moving target in stereotactic ablative body radiotherapy to lung tumors 570KB PDF download
  文献评价指标  
  下载次数:8次 浏览次数:21次