On the dose to a moving target in stereotactic ablative body radiotherapy to lung tumors

Micro-Mini & Nano-Dosimetry & Innovative Technologies in Radiation Therapy

Feygelman, V.^1 ; Dilling, T.J.^1 ; Moros, E.G.^1 ; Zhang, G.G.^1

H. Lee Moffitt Cancer Center, Tampa

FL

33612, United States^1

关键词: Density scaling;    Dose calculation;    Local control;    Moving targets;    Second orders;    Static approximations;    Targeting accuracy;    Tumor control probability;   

Others  :  https://iopscience.iop.org/article/10.1088/1742-6596/777/1/012027/pdf
DOI  :  10.1088/1742-6596/777/1/012027

来源: IOP

【 摘 要 】

This review summarizes the hierarchy of potential dose inaccuracies in lung SABR in terms of their expected clinical impact. The two main terms are targeting accuracy and adequacy of the dose calculation algorithm. One can associate dose-errors at the 50-100% (zero order) and 10-20% (first order) levels with the former and the latter, respectively. At the first order level, strong evidence exists that using dose algorithms which do not account for 3D density scaling is associated with diminished local control. On the other hand, the second-order target dose-errors due to either static approximations to full 4D calculations, or interplay during modulated delivery, are rather unlikely to rise above 5% (conservatively, ≤ 1% tumor control probability change).