Basophils as Key Regulators of Allergic Inflammation and Th2-type Immunity

World Allergy Organization Journal

Bernhard F Gibbs¹ 

[1] Medway School of Pharmacy, University of Kent, Kent, UK

关键词: allergy;    Th2 immunity;    mast cells;    basophils;   

Others  :  824519
DOI  :  10.1097/WOX.0b013e31817a76fb

 received in 2008-02-05, accepted in 2008-04-03,  发布年份 2008

【 摘 要 】

Basophils have long been suspected as playing more than a bystander role in initiating and maintaining allergic disorders, despite their relatively low numbers compared with other effector cells, such as mast cells and eosinophils. In vitro studies clearly demonstrated their propensity to generate proallergic cytokines, such as interleukin 4 and interleukin 13, as well as histamine and leukotrienes after simulation with allergens and innate IgE-dependent triggers. However, only very recently have mouse basophils been identified as key regulators of allergy in vivo, including orchestrating Th2 immunity to protease allergens in the induction phase. This review highlights these exciting advances that go far in unraveling our understanding of basophil function in the orchestration of allergic inflammation.

【 授权许可】

   
2008 World Allergy Organization; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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