Serum 25-hydroxyvitamin D3 and body composition in an elderly cohort from Germany: a cross-sectional study

Nutrition & Metabolism

Monika Neuhäuser-Berthold²  Heinz J Roth¹  Alexandra Jungert² 

[1] Endocrinology & Oncology Department, Limbach Laboratory, 69126, Heidelberg, Germany;Institute of Nutritional Science, Justus-Liebig-University, Goethestrasse 55, 35390, Giessen, Germany

关键词: Elderly;    Fat mass;    Body composition;    25-Hydroxyvitamin D₃;   

Others  :  815363
DOI  :  10.1186/1743-7075-9-42

 received in 2012-03-26, accepted in 2012-05-03,  发布年份 2012

【 摘 要 】

Background

Emerging evidence indicates that there is an association between vitamin D and obesity. The aim of this study was to investigate whether the level of serum 25-hydroxyvitamin D₃ [25(OH)D₃] in the elderly is influenced by parameters of anthropometry and body composition independent of potential confounding lifestyle factors and the level of serum intact parathyroid hormone (iPTH).

Methods

Cross-sectional data of 131 independently living participants (90 women, 41 men; aged 66–96 years) of the longitudinal study on nutrition and health status in senior citizens of Giessen, Germany were analysed. Concentrations of 25(OH)D₃ and iPTH were ascertained by an electrochemiluminescence immunoassay. Body composition was measured by a bioelectrical impedance analysis. We performed univariate and multiple regression analyses to examine the influence of body composition on 25(OH)D₃ with adjustments for age, iPTH and lifestyle factors.

Results

In univariate regression analyses, 25(OH)D₃ was associated with body mass index (BMI), hip circumference and total body fat (TBF) in women, but not in men. Using multiple regression analyses, TBF was shown to be a negative predictor of 25(OH)D₃ levels in women even after controlling for age, lifestyle and iPTH (ß = −0.247; P = 0.016), whereas the associations between BMI, hip circumference and 25(OH)D₃ lost statistical significance after adjusting for iPTH. In men, 25(OH)D₃ was not affected by anthropometric or body composition variables.

Conclusions

The results indicate that 25(OH)D₃ levels are affected by TBF, especially in elderly women, independent of lifestyle factors and iPTH.

【 授权许可】

   
2012 Jungert et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

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