Measuring the lung function in the mouse: the challenge of size

Respiratory Research

Jason HT Bates¹  Charles G Irvin¹ 

[1] Vermont Lung Center, Department of Medicine, College of Medicine, University of Vermont, Room 226, HSRF, 149 Beaumont Avenue, Burlington, VT 05405, USA

关键词: mouse;    mechanics;    lung;    forced oscillation;    asthma;    animal models of disease;    airway;   

Others  :  1227387
DOI  :  10.1186/rr199

 received in 2002-08-30, accepted in 2003-01-14,  发布年份 2003

【 摘 要 】

Measurement of the effects of drugs, mediators and infectious agents on various models of lung disease, as well as assessment of lung function in the intact mouse has the potential for significantly advancing our knowledge of lung disease. However, the small size of the mouse presents significant challenges for the assessment of lung function. Because of compromises made between precision and noninvasiveness, data obtained may have an uncertain bearing on the mechanical response of the lung. Nevertheless, considerable recent progress has been made in developing valid and useful measures of mouse lung function. These advances, resulting in our current ability to measure sophisticated indices of lung function in laboratory animals, are likely to lead to important insights into the mechanisms of lung disease.

【 授权许可】

   
2003 Irvin et al., licensee BioMed Central Ltd

【 图 表 】

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