Interactions between genes and environmental factors in asthma and atopy: new developments

Respiratory Research

Renate Nickel¹  Ulrich Wahn¹  Susanne Lau¹  Claudia Sengler¹ 

[1] Department of Pediatric Pneumology and Immunology, Charité, Humboldt University Berlin, Berlin, Germany

关键词: infection;    genetics;    environment;    atopy;    asthma;   

Others  :  1227413
DOI  :  10.1186/rr179

 received in 2001-04-10, accepted in 2001-07-27,  发布年份 2001

【 摘 要 】

Asthma and associated phenotypes are complex traits most probably caused by an interaction of multiple disease susceptibility genes and environmental factors. Major achievements have occurred in identifying chromosomal regions and polymorphisms in candidate genes linked to or associated with asthma, atopic dermatitis, IgE levels and response to asthma therapy. The aims of this review are to explain the methodology of genetic studies of multifactorial diseases, to summarize chromosomal regions and polymorphisms in candidate genes linked to or associated with asthma and associated traits, to list genetic alterations that may alter response to asthma therapy, and to outline genetic factors that may render individuals more susceptible to asthma and atopy due to environmental changes.

【 授权许可】

   
2002 BioMed Central Ltd

【 图 表 】

Supplementary Figure 1.

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