Clearance of serum solutes by hemofiltration in dogs with severe heat stroke

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine

Jian Chen³  Jin-Hua Chen⁴  Wen-Rui Wang⁵  Hai-Xia Zhan¹  Cheng-Feng Wang¹  Yu-Ying Lan²  Guang-Ming Chen¹ 

[1] Department of Pediatrics, Fuzhou General Hospital of Nanjing Military Command, PLA, Clinical Medical College of Fujian Medical University in Fuzhou General Hospital of Nanjing Military Command, PLA, Dongfang Hospital Affiliated to Xiamen University, NO. 156, Xi Er-Huan North Road, Fuzhou 350025, Fujian Province, China;Fujian University of Traditional Chinese Medicine, Fuzhou 350108, China;Department of Nephrology, Fuzhou General Hospital of Nanjing Military Command, PLA, Clinical Medical College of Fujian Medical University in Fuzhou General Hospital of Nanjing Military Command, PLA, Dongfang Hospital Affiliated to Xiamen University, NO. 156, Xi Er-Huan North Road, Fuzhou 350025, Fujian Province, China;Statistics Room, Fuzhou General Hospital of Nanjing Military Command, PLA, Clinical Medical College of Fujian Medical University in Fuzhou General Hospital of Nanjing Military Command, PLA, Dongfang Hospital Affiliated to Xiamen University, Fuzhou 350025, China;Department of Thoracic Surgery, Fuzhou General Hospital of Nanjing Military Command, PLA, Clinical Medical College of Fujian Medical University in Fuzhou General Hospital of Nanjing Military Command, PLA, Dongfang Hospital Affiliated to Xiamen University, Fuzhou 350025, China

关键词: Solute;    Shock;    Hemofiltration;    Heat stroke;    Dogs;    Clearance;   

Others  :  1152076
DOI  :  10.1186/s13049-014-0049-z

 received in 2013-11-27, accepted in 2014-08-11,  发布年份 2014

【 摘 要 】

Background

We have previously reported that hemofiltration (HF) may be an effective additional means of treating heat stroke when rapid cooling is not effective.

Methods

Dogs were assigned to a heat stroke (control) or heat stroke + hemofiltration (HF) group (n = 8 each group). After heat stroke induction, dogs in the HF group received HF for 3 h. Serum concentrations of interleukin (IL)-10, tumor necrosis factor (TNF)-α, IL-6, blood urea nitrogen (BUN) and creatinine were measured at baseline and 1, 2, and 3 h after heat stroke. Clearance rates of solutes were determined 1, 2, and 3 h after the start of HF.

Results

Serum concentrations of all solutes tended to increase with time after heat stroke in the control group, but decreased (BUN, creatinine) or remained relatively unchanged (TNF-α, IL-6, IL-10) with time in the HF group. Concentrations of all solutes were significantly lower in the HF group compared with the control group at 2 and 3 h (P < 0.05). Clearance rates for small molecular weight solutes were high, while those for larger molecular weight solutes were low.

Conclusion

HF prevents heat stroke-induced increases in serum cytokine concentrations and is effective for clearing small molecular weight solutes from serum, but less effective for clearing larger molecular weight solutes, including TNF-α, IL-6, and IL-10.

【 授权许可】

   
2014 Chen et al.; licensee BioMed Central Ltd.

【 图 表 】

Figure 1.

Figure 2.

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