期刊论文详细信息
World Allergy Organization Journal
The Impact of a Program for Control of Asthma in a Low-Income Setting
Maurício L Barreto3  Pablo Moura Santos4  Eduardo V Ponte4  Carolina Souza-Machado6  Rosana Franco5  Adelmir Souza-Machado2  Alvaro A Cruz1 
[1] ProAR-Faculdade de Medicina da Bahia (FMB), Federal University of Bahia (UFBA), and CNPq, Brazil;Instituto de Ciencias da Saude, UFBA, Brazil;Institute for Collective Health (ISC), UFBA, Brazil;ProAR-Hospital Universitario Professor Edgar Santos, Federal University of Bahia (UFBA), Brazil;ProAR-Hospital Especializado Octavio Mangabeira, Secretaria de Saude do Estado da Bahia, Brazil;Escola de Enfermagem, UFBA, Brazil
关键词: hospitalization;    prevention;    treatment;    control;    asthma;   
Others  :  1180787
DOI  :  10.1097/WOX.0b013e3181dc3383
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【 摘 要 】

The prevalence of asthma is increasing in developing countries and the burden of uncontrolled asthma affects patients, families, and the health system. This is to summarize, evaluate, and discuss previous reports on the impact of a targeted and comprehensive approach to the most severe cases of asthma in a low-income setting. A Program for Control of Asthma (ProAR) was developed in Salvador, Bahia, Brazil, prioritizing the control of severe asthma. By facilitating referrals from the public health system and providing proper multidisciplinary but simple management including education and medication, for free, the Program enrolled 2385 patients in 4 reference clinics. They are offered regular follow up and discharged back to primary health care only when asthma control can be maintained without requirement of a combination of an inhaled corticosteroid and a long-acting β2 agonist. ProAR has markedly reduced health resource utilization and decreased the rate of hospital admissions because of asthma in the entire City (2.8 million inhabitants) by 74%. Moderate to severe rhinitis was associated with lack of control of asthma. The average income of the families in the ProAR was US$2955 a year, and they spent 29% of all their income attempting to control the severe asthma of one member, a unbearable expenditure for a low-income family. The ProAR was shown to be cost-effective, reducing costs to the public health system (US$387 patient/year) and the families (US$789 patient/year). In a low-income setting of Brazil, an intervention prioritizing the control of severe asthma was feasible, effective, and reduced costs.

【 授权许可】

   
2010 World Allergy Organization; licensee BioMed Central Ltd.

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【 参考文献 】
  • [1]Bousquet J, Bousquet PJ, Godard P, Daures JP: The public health implications of asthma. Bull World Heath Organ 2005, 83:548-554.
  • [2]Bousquet J, Khaltaev N: Global surveillance, prevention and control of chronic respiratory diseases A comprehensive approach. World Health Organization, Geneva; 2007:146.
  • [3]Solé D, Wandalsen GF, Camelo-Nunes IC, Naspitz CK: ISAAC-Brazilian Group. Prevalence of symptoms of asthma, rhinitis, and atopic eczema among Brazilian children and adolescents identified by the International Study of Asthma and Allergies in Childhood (ISAAC)-Phase 3. J Pediatr (Rio J) 2006, 82:341-346.
  • [4]Brasil, Ministério da Saúde. Informações de Saúde [http://tabnet.datasus.gov.br/cgi/tabcgi.exe?sih/cnv/mruf.def] webcite Accessed October 20, 2008
  • [5]Brasil, Ministério da Saúde. Informações de Saúde [http://tabnet.datasus.gov.br/cgi/deftohtm.exe?sim/cnv/obtuf.def] webcite Accessed October 23, 2008
  • [6]Neffen H, Fritscher C, Schacht FC, Levy G, Chiarella P, et al.: Asthma control in Latin America: the Asthma Insights and Reality in Latin America (AIRLA) survey. Rev Panam Salud Publica 2005, 17:191-197.
  • [7]Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, et al.: Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood: ISAAC Phases One and Three repeat multi-country cross-sectional surveys. Lancet 2006, 368:733-743.
  • [8]Mavale-Manuel S, Joaquim O, Macome C, Almeida L, Nunes E, et al.: Asthma and allergies in schoolchildren of Maputo. Allergy 2007, 62:265-271.
  • [9]Barnes KC, Grant AV, Hansel NN, Gao P, Dunston GM: African Americans with asthma: genetic insights. Proc Am Thorac Soc 2007, 4:58-68.
  • [10]Martinez FD: Genes, environments, development and asthma: a reappraisal. Eur Respir J 2007, 29:179-184.
  • [11]Nicolaou N, Siddique N, Custovic A: Allergic disease in urban and rural populations: increasing prevalence with increasing urbanization. Allergy 2005, 60:1357-1360.
  • [12]US Department of Health and Human Services The Health Consequences of Involuntary Exposure to Tobacco Smoke: A Report of the Surgeon General Chapter 6 Respiratory Effects in Children from Exposure to Second-hand Smoke 2006. Centers for Disease Control and Prevention, Coordinating Center for Health Promotion, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health;
  • [13]Bousquet J, Khaltaev N, Cruz AA, Denburg J, Fokkens WJ, et al.: Allergic Rhinitis and its Impact on Asthma (ARIA) 2008 update. Allergy 2008, 63(Suppl):8-160. 86
  • [14]Gotzsche PC, Johansen HK, Schmidt LM, Burr ML: House dust mite control measures for asthma. Cochrane database of systematic reviews (Online) 2004, CD001187.
  • [15]de Vries MP, van den Bemt L, Aretz K, Thoonen BP, Muris JW, et al.: House dust mite allergen avoidance and self-management in allergic patients with asthma: randomised controlled trial. Br J Gen Pract 2007, 57:184-190.
  • [16]Luczynska C, Tredwell E, Smeeton N, Burney P: A randomized controlled trial of mite allergen-impermeable bed covers in adult mite-sensitized asthmatics. Clin Exp Allergy 2003, 33:1648-1653.
  • [17]Morgan WJ, Crain EF, Gruchalla RS, O'Connor GT, Kattan M, et al.: Inner-City Asthma Study Group. Results of a home-based environmental intervention among urban children with asthma. N Engl J Med 2004, 351:1068-1080.
  • [18]Wood LG, Garg ML, Powell H, Gibson PG: Lycopene-rich treatments modify noneosinophilic airway inflammation in asthma: proof of concept. Free Radic Res 2008, 42:94-102.
  • [19]Basaran S, Guler-Uysal F, Ergen N, Seydaoglu G, Bingol-Karakoç G, Ufuk Altintas D: Effects of physical exercise on quality of life, exercise capacity and pulmonary function in children with asthma. J Rehabil Med 2006, 38:130-135.
  • [20]Chaudhuri R, Livingston E, McMahon AD, Lafferty J, Fraser I, et al.: Effects of smoking cessation on lung function and airway inflammation in smokers with asthma. Am J Respir Crit Care Med 2006, 174:127-133.
  • [21]World Health Organization (WHO): Model List of Essential Medicines. Geneva, World Health Organization; 2007.
  • [22]Suissa S, Ernst P, Benayoun S, Baltzan M, Cai B: Low-dose inhaled corticosteroids and the prevention of death from asthma. N Engl J Med 2000, 343:332-336.
  • [23]Bacharier LB, Raissy HH, Wilson L, McWilliams B, Strunk RC, Kelly HW: Long-term effect of budesonide on hypothalamic-pituitary-adrenal axis function in children with mild to moderate asthma. Pediatrics 2004, 113:1693-1699.
  • [24]Pauwels RA, Löfdahl CG, Postma DS, Tattersfield AE, O'Byrne P, Barnes PJ, Ullman A: Effect of inhaled formoterol and budesonide on exacerbations of asthma. Formoterol and Corticosteroids Establishing Therapy (FACET) International Study Group N Engl J Med 1997, 337:1405-1411.
  • [25]National Asthma Education and Prevention Program (NHLBI, NIH)-Expert Panel Report 3 (Publication No. 07-4051) In Guidelines for the Diagnosis and Management of Asthma. Bethesda, US Department of Health and Human Services; 2007:416.
  • [26]Global Strategy for Asthma Prevention and Management, full report Global Initiative for Asthma (GINA) 2006, 109.
  • [27]Haahtela T, Tuomisto LE, Pietinalho A, Klaukka T, Erhola M, et al.: A year asthma programme in Finland: major change for the better. Thorax 2006, 61:663-670.
  • [28]Evans R, Gergen PJ, Mitchell H, Kattan M, Kercsmar C, et al.: A randomized clinical trial to reduce asthma morbidity among inner-city children: results of the National Cooperative Inner-City Asthma Study. J Pediatr 1999, 135:332-338.
  • [29]Fischer GB, Camargos PA, Mocelin HT: The burden of asthma in children: a Latin American perspective. Paediatr Respir Rev 2005, 6:8-13.
  • [30]Global Strategy for Asthma Management and Prevention Global Initiative for Asthma (GINA) 2002.
  • [31]American Thoracic Society (ATS): Standardization of Spirometry. 1994 Update. Am J Respir Crit Care Med 1995, 152:1107-1136.
  • [32]Pereira CAC, Barreto SP, Simões JG, Pereira FWL, Gerstler JG, Nakatani J: Valores de Referência para Espirometria em uma amostra da população brasileira adulta. J Bras Pneumol 1992, 18:10-12.
  • [33]Okie S: Fighting HIV: lessons from Brazil. N Engl J Med 2006, 54:191-197.
  • [34]Juniper EF, Guyatt GH, Epstein RS: Evaluation of impairment of health-related quality of life in asthma: development of a questionnaire for use in clinical trials. Thorax 1992, 47:76-83.
  • [35]Leite M, Ponte EV, Petroni J, D'Oliveira A Jr, Pizzichini E, Cruz AA: Evaluation of the Asthma Control Questionnaire validated for use in Brazil. J Bras Pneumol 2008, 34:756-763.
  • [36]Universidade Federal da Bahia, Instituto de Saúde Coletiva: Programa de Economia da Saúde. [http://www.pecs.ufba.br/scripts/arquivos/default.asp] webcite Accessed November 9, 2008
  • [37]Eddy D: Cost-effectiveness analysis: a conversation with my father. JAMA 1992, 267:1669-1675.
  • [38]Drummond M, O'Brien B, Stoddart GL, Torrance GW: Methods for the Economic Evaluation. In Methods for the Economic Evaluation. London: Oxford University; 1997.
  • [39]Ponte E, Franco RA, Souza-Machado A, Souza-Machado C, Cruz AA: Impact that a program to control severe asthma has on the use of Unified Health System resources in Brazil. J Bras Pneumol 2007, 33:15-19.
  • [40]Franco R, Nascimento HF, Cruz AA, Santos AC, Souza-Machado C, et al.: The economic impact of severe asthma to low-income families. Allergy 2009, 64:478-483.
  • [41]Souza-Machado C, Souza-Machado A, Franco R, Ponte EV, Barreto ML, et al.: Rapid reduction in hospitalizations after an intervention to manage severe asthma. Eur Respir J 2010, 35:1-7.
  • [42]Franco R, Santos AC, do Nascimento HF, Souza-Machado C, Ponte E, et al.: Cost-effectiveness analysis of a state funded programme for control of severe asthma. BMC Public Health 2007, 7:82. BioMed Central Full Text
  • [43]Ponte EV, Franco R, Nascimento HF, Souza-Machado A, Cunha S, et al.: Lack of control of severe asthma is associated with co-existence of moderate-to-severe rhinitis. Allergy 2008, 63:564-569.
  • [44]Kocevar VS, Thomas J, Jonsson L, Yin DD, Bisgaard H: Association between allergic rhinitis and hospital resource use among asthmatic children in Norway. Allergy 2005, 60:338-342.
  • [45]Thomas M, Kocevar VS, Zhang Q, Yin DD, Price D: Asthma related heath resource use among asthmatic children with and without concomitant allergic rhinitis. Pediatrics 2005, 115:129-134.
  • [46]Price D, Zhang Q, Kocevar VS, Yin DD, Thomas M: Effect of a concomitant diagnosis of allergic rhinitis on astma-related heath care use by adults. Clin Exp Allergy 2005, 35:282-287.
  • [47]Cruz AA: The united airways require an holistic approach to management. Allergy 2005, 60:871-874.
  • [48]Cruz AA, Bousquet PJ: The unbearable cost of severe asthma in underprivileged populations. Allergy 2009, 64:319-321.
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