Multi-institutional comparison of volumetric modulated arc therapy vs. intensity-modulated radiation therapy for head-and-neck cancer: a planning study

Radiation Oncology

Corine van Vliet-Vroegindeweij⁵  Rob JW Louwe¹  Martina C Kunze-Busch³  Danny Schuring²  Erik W Korevaar⁷  Mark P Arends⁶  Dirk Van Gestel⁸  Andrea Holt⁴ 

[1] Present address: Department of Radiation Oncology, Wellington Blood and Cancer Centre, Wellington, New Zealand;Department of Radiation Oncology, Catharina Hospital, Eindhoven, The Netherlands;Department of Radiation Oncology, Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands;Present address: Department of Radiation Oncology, University of Duisburg-Essen, Essen, Germany;Department of Radiation Oncology, The Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, Amsterdam, CX 1066, The Netherlands;Radiotherapeutic Institute Friesland, Leeuwarden, The Netherlands;Department of Radiation Oncology,University Medical Center Groningen, University of Groningen, Groningen, The Netherlands;Department of Radiation Oncology, Antwerp University Radiotherapy, UZA/ZNA, Antwerp, Belgium

关键词: SmartArc;    Multi-institutional collaboration;    Intensity-modulated radiation therapy;    Volumetric modulated arc therapy;    Simultaneous integrated boost;    Head-and-neck cancer;   

Others  :  1154644
DOI  :  10.1186/1748-717X-8-26

 received in 2012-07-25, accepted in 2012-12-28,  发布年份 2013

【 摘 要 】

Background

Compared to static beam Intensity-Modulated Radiation Therapy (IMRT), the main advantage of Volumetric Modulated Arc Therapy (VMAT) is a shortened delivery time, which leads to improved patient comfort and possibly smaller intra-fraction movements. This study aims at a treatment planner-independent comparison of radiotherapy treatment planning of IMRT and VMAT for head-and-neck cancer performed by several institutes and based on the same CT- and contouring data.

Methods

Five institutes generated IMRT and VMAT plans for five oropharyngeal cancer patients using either Pinnacle³ or Oncentra Masterplan to be delivered on Elekta linear accelerators.

Results

Comparison of VMAT and IMRT plans within the same patient and institute showed significantly better sparing for almost all OARs with VMAT. The average mean dose to the parotid glands and oral cavity was reduced from 27.2 Gy and 39.4 Gy for IMRT to 25.0 Gy and 36.7 Gy for VMAT, respectively. The dose conformity at 95% of the prescribed dose for PTV_boost and PTV_total was 1.45 and 1.62 for IMRT and 1.37 and 1.50 for VMAT, respectively. The average effective delivery time was reduced from 13:15 min for IMRT to 5:54 min for VMAT.

Conclusions

Independently of institution-specific optimization strategies, the quality of the VMAT plans including double arcs was superior to step-and-shoot IMRT plans including 5–9 beam ports, while the effective treatment delivery time was shortened by ~50% with VMAT.

【 授权许可】

   
2013 Holt et al; licensee BioMed Central Ltd.

【 图 表 】

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