Bisphenol a and the female reproductive tract: an overview of recent laboratory evidence and epidemiological studies

Reproductive Biology and Endocrinology

Massimo Moscarini¹  Roberto Marci³  Alberto Mantovani²  Valentina Giovanale¹  Maddalena Mallozzi¹  Noemi Di Segni¹  Donatella Caserta¹ 

[1] Department of Gynecology-Obstetrics and Urological Sciences, “Sapienza”, University of Rome, S. Andrea Hospital, Rome, Italy;Food and Veterinary Toxicology Section, Istituto Superiore di Sanità, Roma, Italy;Department of Biomedical Sciences and Advanced Therapies, Section of Obstetrics and Gynaecology, University of Ferrara, Ferrara, Italy

关键词: Genital tract;    Reproductive health;    Fertility;    Endocrine disruptors;    Bisphenol A;   

Others  :  804260
DOI  :  10.1186/1477-7827-12-37

 received in 2014-01-31, accepted in 2014-05-01,  发布年份 2014

【 摘 要 】

Bisphenol A (BPA) is a high production volume monomer used for making a wide variety of polycarbonate plastics and resins. A large body of evidence links BPA to endocrine disruption in laboratory animals, and a growing number of epidemiological studies support a link with health disorders in humans. The aim of this review is to summarize the recent experimental studies describing the effects and mechanisms of BPA on the female genital tract and to compare them to the current knowledge regarding the impact of BPA impact on female reproductive health. In particular, BPA has been correlated with alterations in hypothalamic-pituitary hormonal production, reduced oocyte quality due to perinatal and adulthood exposure, defective uterine receptivity and the pathogenesis of polycystic ovary syndrome. Researchers have reported conflicting results regarding the effect of BPA on premature puberty and endometriosis development. Experimental studies suggest that BPA’s mechanism of action is related to life stage and that its effect on the female reproductive system may involve agonism with estrogen nuclear receptors as well as other mechanisms (steroid biosynthesis inhibition). Notwithstanding uncertainties and knowledge gaps, the available evidence should be seen as a sufficient grounds to take precautionary actions against excess exposure to BPA.

【 授权许可】

   
2014 Caserta et al.; licensee BioMed Central Ltd.

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