Eliminating malaria vectors

Particle and Fibre Toxicology

Michael T White³  Nicodem J Govella⁴  John E Gimnig⁶  Amri S Zomboko²  Chadwick Sikaala⁵  Aklilu Seyoum¹  Gerry F Killeen¹ 

[1] Vector Biology Department, Liverpool School of Tropical Medicine, Liverpool, UK;Monitoring & Evaluation Thematic Group, Ifakara Health Institute, Dar es Salaam, United Republic of Tanzania;Department of Infectious Disease Epidemiology, Medical Research Council Centre for Outbreak Analysis & Modelling, Imperial College London, London, UK;Environmental Health & Ecological Sciences, Ifakara Health Institute, Dar es Salaam, United Republic of Tanzania;National Malaria Control Centre, Lusaka, Zambia;Division of Parasitic Diseases, Centers for Disease Control and Prevention, Chamblee, Georgia, USA

关键词: Behaviour;    Resistance;    Elimination;    Eradication;    Mosquito;    Anopheles;    Control;    Plasmodium;   

Others  :  1227009
DOI  :  10.1186/1756-3305-6-172

 received in 2013-02-14, accepted in 2013-06-03,  发布年份 2013

【 摘 要 】

Malaria vectors which predominantly feed indoors upon humans have been locally eliminated from several settings with insecticide treated nets (ITNs), indoor residual spraying or larval source management. Recent dramatic declines of An. gambiae in east Africa with imperfect ITN coverage suggest mosquito populations can rapidly collapse when forced below realistically achievable, non-zero thresholds of density and supporting resource availability. Here we explain why insecticide-based mosquito elimination strategies are feasible, desirable and can be extended to a wider variety of species by expanding the vector control arsenal to cover a broader spectrum of the resources they need to survive. The greatest advantage of eliminating mosquitoes, rather than merely controlling them, is that this precludes local selection for behavioural or physiological resistance traits. The greatest challenges are therefore to achieve high biological coverage of targeted resources rapidly enough to prevent local emergence of resistance and to then continually exclude, monitor for and respond to re-invasion from external populations.

【 授权许可】

   
2013 Killeen et al.; licensee BioMed Central Ltd.

【 图 表 】

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