Prospective double-blind randomized study on the efficacy and safety of an n-3 fatty acid enriched intravenous fat emulsion in postsurgical gastric and colorectal cancer patients

Nutrition Journal

Jaw-Yuan Wang³  Ming-Tsan Lin⁶  Ming-Yang Wang⁶  Ming-Hsun Wu⁶  Jui-Fen Chuang⁴  Chao-Wen Chen⁷  Ying-Ling Shih¹  Li-Chu Sun¹  Chien-Yu Lu⁸  Ching-Wen Huang⁵  Hsiang-Lin Tsai²  Jin-Ming Wu⁶  Cheng-Jen Ma³ 

[1] Nutrition Support Team, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan;School of Medical and Health Sciences, Fooyin University, Kaohsiung, Taiwan;Graduate Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Institute of Clinical Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Surgery, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;Department of Surgery, National Taiwan University Hospital, National Taiwan University, No. 7 Chung-Shan South Road, Taipei 100, Taiwan;Department of Emergency Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;Division of Gastroenterology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan

关键词: Colorectal cancer;    Gastric cancer;    Fish oils;    LCT/MCT;    n-3 fatty acids;    Lipid emulsion;   

Others  :  1132307
DOI  :  10.1186/1475-2891-14-9

 received in 2014-08-12, accepted in 2014-12-23,  发布年份 2015

【 摘 要 】

Background

A lipid emulsion composed of soybean oil (long-chain triglycerides, LCT), medium-chain triglycerides (MCT) and n-3 poly-unsaturated fatty acids (PUFAs) was evaluated for immune-modulation efficacy, safety, and tolerance in patients undergoing major surgery for gastric and colorectal cancer.

Methods

In a prospective, randomized, double-blind study, 99 patients with gastric and colorectal cancer receiving elective surgery were recruited and randomly assigned to either the study group, receiving the n-3 PUFAs enriched intravenous fat emulsion (IVFE), or the control group, receiving a lipid emulsion comprised of soybean oil and MCTs (0.8 – 1.5 g · kg^-1 · day^-1) as part of total parenteral nutrition (TPN) regimen from surgery (day -1) up to post-operative day 7. Safety and efficacy parameters were assessed on day -1 and post-operative visits on day 1, 3, and 7. Adverse events were documented daily and compared between the groups.

Results

Pro-inflammatory markers, laboratory parameters, and adverse events did not differ prominently between the 2 groups, with the exception of net changes (day 7 minus day -1) of free fatty acids (FFAs), triglyceride, and high-density lipoprotein (HDL). Net decrease of FFAs was remarkably higher in the study group, while the net increase of triglyceride and decrease of HDL was significantly lower.

Conclusions

The n-3 PUFA-enriched IVFE showed improvements in lipid metabolism. In respect of efficacy, safety and tolerance both IVFE were comparable. In patients with severe stress, there is an inflammation-attenuating effect of n-3 PUFAs. Further, adequately powered clinical trials will be necessary to address this question in postsurgical GI cancer patients.

Trial registration

US ClinicalTrials.govNCT00798447.

【 授权许可】

   
2015 Ma et al.; licensee BioMed Central.

【 图 表 】

Figure 1.

Figure 2.

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