Lung clearance index in adults with non-cystic fibrosis bronchiectasis

Respiratory Research

Salman Siddiqui¹  Alex Horsley³  Ian Pavord¹  Christopher E Brightling¹  Simon Range¹  Chandra Ohri¹  Per Gustafsson²  Amisha Singapuri¹  Marcia Soares¹  Alys Scadding¹  Sherif Gonem⁴ 

[1] Institute for Lung Health, University of Leicester, Leicester, UK;Department of Paediatrics, Central Hospital, Skövde, Sweden;Institute of Inflammation and Repair, University of Manchester, Manchester, UK;Respiratory BRU, Glenfield Hospital, Groby Road, Leicester LE3 9QP, UK

关键词: Ventilation heterogeneity;    Lung clearance index;    Bronchiectasis;   

Others  :  790268
DOI  :  10.1186/1465-9921-15-59

 received in 2013-12-02, accepted in 2014-05-08,  发布年份 2014

【 摘 要 】

Background

Lung clearance index (LCI) is a measure of abnormal ventilation distribution derived from the multiple breath inert gas washout (MBW) technique. We aimed to determine the clinical utility of LCI in non-CF bronchiectasis, and to assess two novel MBW parameters that distinguish between increases in LCI due to specific ventilation inequality (LCI_vent) and increased respiratory dead space (LCI_ds).

Methods

Forty-three patients with non-CF bronchiectasis and 18 healthy control subjects underwent MBW using the sulphur hexafluoride wash-in technique, and data from 40 adults with CF were re-analysed. LCI_vent and LCI_ds were calculated using a theoretical two-compartment lung model, and represent the proportional increase in LCI above its ideal value due to specific ventilation inequality and increased respiratory dead space, respectively.

Results

LCI was significantly raised in patients with non-CF bronchiectasis compared to healthy controls (9.99 versus 7.28, p < 0.01), and discriminated well between these two groups (area under receiver operating curve = 0.90, versus 0.83 for forced expiratory volume in one second [% predicted]). LCI, LCI_vent and LCI_ds were repeatable (intraclass correlation coefficient > 0.75), and correlated significantly with measures of spirometric airflow obstruction.

Conclusion

LCI is repeatable, discriminatory, and is associated with spirometric airflow obstruction in patients with non-CF bronchiectasis. LCI_vent and LCI_ds are a practical and repeatable alternative to phase III slope analysis and may allow a further level of mechanistic information to be extracted from the MBW test in patients with severe ventilation heterogeneity.

【 授权许可】

   
2014 Gonem et al.; licensee BioMed Central Ltd.

【 图 表 】

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