期刊论文详细信息
Particle and Fibre Toxicology
Environmental contamination with Toxocara eggs: a quantitative approach to estimate the relative contributions of dogs, cats and foxes, and to assess the efficacy of advised interventions in dogs
Harm W. Ploeger2  Frits Franssen1  Jaap A. Wagenaar3  Lapo Mughini-Gras1  Rolf Nijsse2 
[1] National Institute for Public Health and the Environment, Centre for Infectious Disease Control, Bilthoven 3720 BA, The Netherlands;Department of Infectious Diseases and Immunology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, 3508 TD, The Netherlands;Central Veterinary Institute of Wageningen UR, Houtribweg 39, Lelystad, 8221 RA, The Netherlands
关键词: Clean-up;    Deworming;    Environment;    Contamination;    Contribution;    Foxes;    Cats;    Dogs;    Eggs;    Toxocara;   
Others  :  1222139
DOI  :  10.1186/s13071-015-1009-9
 received in 2015-04-21, accepted in 2015-07-14,  发布年份 2015
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【 摘 要 】

Background

Environmental contamination with Toxocara eggs is considered the main source of human toxocariasis. The contribution of different groups of hosts to this contamination is largely unknown. Current deworming advices focus mainly on dogs. However, controversy exists about blind deworming regimens for >6-month-old dogs, as most of them do not actually shed Toxocara eggs. We aim to estimate the contribution of different non-juvenile hosts to the environmental Toxocara egg contamination and to assess the effects of different Toxocara-reducing interventions for dogs.

Methods

A stochastic model was developed to quantify the relative contribution to the environmental contamination with Toxocara eggs of household dogs, household cats, stray cats, and foxes, all older than 6 months in areas with varying urbanization degrees. The model was built upon an existing model developed by Morgan et al. (2013). We used both original and published data on host density, prevalence and intensity of infection, coprophagic behaviour, faeces disposal by owners, and cats’ outdoor access. Scenario analyses were performed to assess the expected reduction in dogs’ egg output according to different deworming regimens and faeces clean-up compliances. Estimates referred to the Netherlands, a country free of stray dogs.

Results

Household dogs accounted for 39 % of the overall egg output of >6-month-old hosts in the Netherlands, followed by stray cats (27 %), household cats (19 %), and foxes (15 %). In urban areas, egg output was dominated by stray cats (81 %). Intervention scenarios revealed that only with a high compliance (90 %) to the four times a year deworming advice, dogs’ contribution would drop from 39 to 28 %. Alternatively, when 50 % of owners would always remove their dogs’ faeces, dogs’ contribution would drop to 20 %.

Conclusion

Among final hosts of Toxocara older than 6 months, dogs are the main contributors to the environmental egg contamination, though cats in total (i.e. both owned and stray) transcend this contribution. A higher than expected compliance to deworming advice is necessary to reduce dogs’ egg output meaningfully. Actions focusing solely on household dogs and cats are unlikely to sufficiently reduce environmental contamination with eggs, as stray cats and foxes are also important contributors.

【 授权许可】

   
2015 Nijsse et al.

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【 参考文献 】
  • [1]Pinelli E, Brandes S, Dormans J, Gremmer E, van Loveren H. Infection with the roundworm Toxocara canis leads to exacerbation of experimental allergic airway inflammation. Clin Exp Allergy. 2008; 38(4):649-58.
  • [2]Pinelli E, Herremans T, Harms MG, Hoek D, Kortbeek LM. Toxocara and Ascaris seropositivity among patients suspected of visceral and ocular larva migrans in the Netherlands: Trends from 1998 to 2009. Eur J Clin Microbiol Infect Dis. 2011; 30(7):873-9.
  • [3]Aranzamendi C, Sofronic-Milosavljevic L, Pinelli E. Helminths: Immunoregulation and inflammatory diseases-which side are Trichinella spp. and Toxocara spp. on? J Parasitol Res. 2013; 2013:329438.
  • [4]Fisher M. Toxocara cati: An underestimated zoonotic agent. Trends Parasitol. 2003; 19(4):167-70.
  • [5]de Melker HE, van der Peet TE, Berbers WAM et al.. Pilot-onderzoek voor het Pienter-project: Seroprevalenties voor bof, mazelen, rubella, kinkhoest, Toxoplasma gondii, Toxocara, Trichinella spiralis en hepatitis A. 213675004. Dutch Institute of Public Health and the Environment, Bilthoven; 1995.
  • [6]Borgsteede FH, Holzhauer M, Herder FL, Veldhuis-Wolterbeek EG, Hegeman C. Toxocara vitulorum in suckling calves in the Netherlands. Res Vet Sci. 2012; 92(2):254-6.
  • [7]Morgan ER, Azam D, Pegler K. Quantifying sources of environmental contamination with Toxocara spp. eggs. Vet Parasitol. 2013;193(4):390–7.
  • [8]ESCCAP, September 2010-last update, Guideline 01 2nd edition Worm Control in Dogs and Cats. Available:. http://www. esccap.org/uploads/docs/nkzqxmxn_esccapgl1endoguidelines.pdf webcite
  • [9]Nijsse R, Ploeger HW, Wagenaar JA, Mughini-Gras L. Toxocara canis in household dogs: Prevalence, risk factors and owners’ attitude towards deworming. Parasitol Res. 2014; 114(2):561-9.
  • [10]Barriga OO. A critical look at the importance, prevalence and control of toxocariasis and the possibilities of immunological control. Vet Parasitol. 1988; 29(2–3):195-234.
  • [11]O’Lorcain P. Epidemiology of Toxocara spp. in stray dogs and cats in Dublin, Ireland. J Helminthol. 1994; 68(4):331-6.
  • [12]Saeed IS, Kapel CM. Population dynamics and epidemiology of Toxocara canis in Danish red foxes. J Parasitol. 2006; 92(6):1196-1201.
  • [13]Sager H, Moret C, Grimm F, Deplazes P, Doherr MG, Gottstein B. Coprological study on intestinal helminths in Swiss dogs: Temporal aspects of anthelminthic treatment. Parasitol Res. 2006; 98(4):333-8.
  • [14]Claerebout E, Casaert S, Dalemans AC et al.. Giardia and other intestinal parasites in different dog populations in northern Belgium. Vet Parasitol. 2009; 161(1–2):41-6.
  • [15]Overgaauw PA, van Zutphen L, Hoek D et al.. Zoonotic parasites in fecal samples and fur from dogs and cats in the Netherlands. Vet Parasitol. 2009; 163(1–2):115-22.
  • [16]Reperant LA, Hegglin D, Fischer C, Kohler L, Weber JM, Deplazes P. Influence of urbanization on the epidemiology of intestinal helminths of the red fox (Vulpes vulpes) in Geneva, Switzerland. Parasitol Res. 2007; 101(3):605-11.
  • [17]Beugnet F, Bourdeau P, Chalvet-Monfray K et al.. Parasites of domestic owned cats in Europe: Co-infestations and risk factors. Parasit Vectors. 2014; 7:291. BioMed Central Full Text
  • [18]Mughini Gras L, Smid JH, Wagenaar JA et al.. Increased risk for Campylobacter jejuni and C. coli infection of pet origin in dog owners and evidence for genetic association between strains causing infection in humans and their pets. Epidemiol Infect. 2013; 141(12):2526-35.
  • [19]Mughini-Gras L, Enserink R, Friesema I, Heck M, van Duynhoven Y, van Pelt W. Risk factors for human salmonellosis originating from pigs, cattle, broiler chickens and egg laying hens: A combined case–control and source attribution analysis. PLoS One. 2014; 9(2):e87933.
  • [20]HAS Den Bosch. Feiten & cijfers - gezelschapsdierensector. 2011;ISBN 978-90-817710-1-6. Den Bosch: HAS Kennistransfer, Hogeschool HAS Den Bosch. 2011. Available:http://www.hasdenbosch.nl/sites/default/files/null/Feiten%20%26%20Cijfers%20van%20de%20Gezelschapsdierensector%202011.pdf.
  • [21]Nijsse R, Mughini-Gras L, Wagenaar JA, Ploeger HW. Coprophagy in dogs interferes in the diagnosis of parasitic infections by faecal examination. Vet Parasitol. 2014; 204(3–4):304-9.
  • [22]Cherbut C, Ruckebusch Y. The effect of indigestible particles on digestive transit time and colonic motility in dogs and pigs. Br J Nutr. 1985; 53(3):549-57.
  • [23]Diez M, Hornick JL, Baldwin P, Van Eenaeme C, Istasse L. The influence of sugar-beet fibre, guar gum and inulin on nutrient digestibility, water consumption and plasma metabolites in healthy beagle dogs. Res Vet Sci. 1998; 64(2):91-6.
  • [24]Burkhalter TM, Merchen NR, Bauer LL et al.. The ratio of insoluble to soluble fiber components in soybean hulls affects ileal and total-tract nutrient digestibilities and fecal characteristics of dogs. J Nutr. 2001; 131(7):1978-85.
  • [25]Grieshop CM, Flickinger EA, Fahey GC. Oral administration of arabinogalactan affects immune status and fecal microbial populations in dogs. J Nutr. 2002; 132(3):478-82.
  • [26]Flickinger EA, Schreijen EM, Patil AR et al.. Nutrient digestibilities, microbial populations, and protein catabolites as affected by fructan supplementation of dog diets. J Anim Sci. 2003; 81(8):2008-18.
  • [27]Swanson KS, Kuzmuk KN, Schook LB, Fahey GC. Diet affects nutrient digestibility, hematology, and serum chemistry of senior and weanling dogs. J Anim Sci. 2004; 82(6):1713-24.
  • [28]Quigley JD, Campbell JM, Polo J, Russell LE. Effects of spray-dried animal plasma on intake and apparent digestibility in dogs. J Anim Sci. 2004; 82(6):1685-92.
  • [29]Brambillasca S, Purtscher F, Britos A, Repetto JL, Cajarville C. Digestibility, fecal characteristics, and plasma glucose and urea in dogs fed a commercial dog food once or three times daily. Can Vet J. 2010; 51(2):190-4.
  • [30]Vasupen K, Yuangklang C, Beynen AC, Einerhand AWC. Effect of dietary polydextrose on feces consistency and macronutrient digestibility in healthy dogs. Am J Anim Vet Sci. 2011; 6(3):105-11.
  • [31]Beloshapka AN, Duclos LM, Vester Boler BM, Swanson KS. Effects of inulin or yeast cell-wall extract on nutrient digestibility, fecal fermentative end-product concentrations, and blood metabolite concentrations in adult dogs fed raw meat-based diets. Am J Vet Res. 2012; 73(7):1016-23.
  • [32]Sabchuk TT, Félix AP, Comin JG, Alarça LG, de Oliveira SG, Maiorka A. Digestibility and behavior of dogs housed in kennels or metabolic cages. R. Bras Zootec. 2012; 41(1):118-22.
  • [33]Brambillasca S, Britos A, Deluca C, Fraga M, Cajarville C. Addition of citrus pulp and apple pomace in diets for dogs: Influence on fermentation kinetics, digestion, faecal characteristics and bacterial populations. Arch Anim Nutr. 2013; 67(6):492-502.
  • [34]Sowemimo OA. Prevalence and intensity of Toxocara canis (Werner, 1782) in dogs and its potential public health significance in Ile-Ife, Nigeria. J Helminthol. 2007; 81(4):433-8.
  • [35]Hesta M, Hoornaert E, Verlinden A, Janssens GP. The effect of oligofructose on urea metabolism and faecal odour components in cats. J Anim Physiol Anim Nutr (Berl). 2005; 89(3–6):208-14.
  • [36]Barry KA, Wojcicki BJ, Middelbos IS, Vester BM, Swanson KS, Fahey GC. Dietary cellulose, fructooligosaccharides, and pectin modify fecal protein catabolites and microbial populations in adult cats. J Anim Sci. 2010; 88(9):2978-87.
  • [37]Vester BM, Beloshapka AN, Middelbos IS et al.. Evaluation of nutrient digestibility and fecal characteristics of exotic felids fed horse- or beef-based diets: Use of the domestic cat as a model for exotic felids. Zoo Biol. 2010; 29(4):432-48.
  • [38]Kanakupt K, Vester Boler BM, Dunsford BR, Fahey GC. Effects of short-chain fructooligosaccharides and galactooligosaccharides, individually and in combination, on nutrient digestibility, fecal fermentative metabolite concentrations, and large bowel microbial ecology of healthy adults cats. J Anim Sci. 2011; 89(5):1376-84.
  • [39]Kerr KR, Beloshapka AN, Morris CL et al.. Evaluation of four raw meat diets using domestic cats, captive exotic felids, and cecectomized roosters. J Anim Sci. 2013; 91(1):225-37.
  • [40]Sowemimo OA. Prevalence and intensity of gastrointestinal parasites of domestic cats in Ode - Irele and Oyo communities, southwest Nigeria. J Parasitol Vector Biol. 2012; 4(1):7-13.
  • [41]Franssen F, Nijsse R, Mulder J et al.. Increase in number of helminth species from Dutch red foxes over a 35-year period. Parasit Vectors. 2014; 7:166. BioMed Central Full Text
  • [42]Nissen S, Thamsborg SM, Kania PW, Leifsson PS, Dalsgaard A, Johansen MV. Population dynamics and host reactions in young foxes following experimental infection with the minute intestinal fluke. Haplorchis pumilio. Parasit Vectors. 2013; 6:4. BioMed Central Full Text
  • [43]Dubey JP. Patent Toxocara canis infection in ascarid-naive dogs. J Parasitol. 1978; 64(6):1021-23.
  • [44]Parsons JC. Ascarid infections of cats and dogs. Vet Clin North Am Small Anim Pract. 1987; 17(6):1307-39.
  • [45]Taira K, Saeed I, Permin A, Kapel CM. Zoonotic risk of Toxocara canis infection through consumption of pig or poultry viscera. Vet Parasitol. 2004; 121(1–2):115-24.
  • [46]Muijen T. Vossen in Rotterdam. Omgaan met vossen in Rotterdam. bSR-rapport 236. Rotterdam: Bureau stadsnatuur. 2014. Available:http://www.rotterdam.nl/Clusters/Maatschappelijke%20ontwikkeling/Document%202014/Sport%20en%20Cultuur/bSR-rapport-236-Omgaan_met_vossen_in_Rotterdam.pdf
  • [47]Horn JA, Mateus-Pinilla N, Warner RE, Heske EJ. Home range, habitat use, and activity patterns of free-roaming domestic cats. J Wildl Manage. 2011; 75(5):1177-85.
  • [48]Spotte S. Free-ranging cats: Behavior, ecology, management. 1st ed. Wiley, Hoboken; 2014.
  • [49]Greve JH. Age resistance to Toxocara canis in ascarid-free dogs. Am J Vet Res. 1971; 32(8):1185-92.
  • [50]Overgaauw PA, Boersema JH. Assessment of an educational campaign by practicing veterinarians in the Netherlands on human and animal Toxocara infections. Tijdschr Diergeneeskd. 1996; 121(21):615-18.
  • [51]Bajer A, Bednarska M, Rodo A. Risk factors and control of intestinal parasite infections in sled dogs in Poland. Vet Parasitol. 2011; 175(3–4):343-50.
  • [52]Becker AC, Rohen M, Epe C, Schnieder T. Prevalence of endoparasites in stray and fostered dogs and cats in northern Germany. Parasitol Res. 2012; 111(2):849-57.
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