Anatomical correlates of blepharospasm

Translational Neurodegeneration

Mark Hallett³  John L Ostuni²  Muslimah Ali Najee-ullah³  Anastasia Ford¹  Silvina G Horovitz³ 

[1] Department of Psychology, University of Florida, Gainesville, FL, USA;Office of the Clinical Director, National Institute of Neurological Disorders and Stroke, Bethesda, MD, USA;Human Motor Control Section, Medical Neurology Branch, National Institute of Neurological Disorders and Stroke, 10 Center Drive, Bdg10/7D37, Bethesda, MD, USA

关键词: Diffusion weighted imaging;    Magnetic resonance imaging;    Volumetric MRI;    Dystonia;    Blepharospasm;   

Others  :  838960
DOI  :  10.1186/2047-9158-1-12

 received in 2012-04-23, accepted in 2012-06-07,  发布年份 2012

【 摘 要 】

Background

Focal dystonia is a neurological disorder characterized by unwanted muscle spasms. Blepharospasm is a focal dystonia producing an involuntary closure of the eyelid. Its etiology is unknown.

Objective

To investigate if there are structural changes in the white and grey matter of blepharospasm patients, and if the changes are related to disease features.

Methods

T1 and diffusion-weighted magnetic resonance imaging scans were collected from 14 female blepharospasm patients and 14 healthy matched controls. Grey matter volumes, fractional anisotropy (FA), and mean diffusivity maps were compared between the groups. Based on grey matter differences within the facial portion of the primary motor cortex, the corticobulbar tract was traced and compared between groups.

Results

Changes in grey matter in patients included the facial portion of the sensorimotor area and anterior cingulate gyrus. These changes did not correlate with disease duration. Corticobulbar tract volume and peak tract connectivity were decreased in patients compared with controls. There were no significant differences in FA or mean diffusivity between groups.

Conclusions

Grey matter changes within the primary sensorimotor and the anterior cingulate cortices in blepharospasm patients may help explain involuntary eyelid closure and the abnormal sensations often reported in this condition.

【 授权许可】

   
2012 Horovitz et al.; licensee BioMed Central Ltd.

【 图 表 】

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