Improved longitudinal length accuracy of gross tumor volume delineation with diffusion weighted magnetic resonance imaging for esophageal squamous cell carcinoma

Radiation Oncology

Joe Y Chang⁴  Chen Yao⁶  Hui Liu¹  Xue-Ying Li⁶  Junichi Asaumi⁵  Xian-Shu Gao²  Gao-Feng Shi¹  Dong-Liang Hou³ 

[1] Department of Radiology, Hebei Medical University Fourth Hospital, Shijiazhuang 050011, China;Department of Radiation Oncology, Peking University First Hospital, Beijing 100034, China;Department of Radiation Oncology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China;Department of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA;Department of Oral and Maxillofacial Radiology, Field of Tumor Biology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 5-1, Shikata-cho, 2-Chome, Okayama 700-8525, Japan;Department of Medical Statistics, Peking University First Hospital, Beijing 100034, China

关键词: Gross tumor volume;    Diffusion weighted imaging;    Magnetic resonance imaging;    Esophageal squamous cell carcinoma;   

Others  :  1153533
DOI  :  10.1186/1748-717X-8-169

 received in 2013-04-06, accepted in 2013-07-01,  发布年份 2013

【 摘 要 】

Background

To analyze the longitudinal length accuracy of gross tumor volume (GTV) delineation with diffusion weighted magnetic resonance imaging for esophageal squamous cell carcinoma (SCC).

Methods

Forty-two patients from December 2011 to June 2012 with esophageal SCC who underwent radical surgery were analyzed. Routine computed tomography (CT) scan, T2-weighted MRI and diffusion weighted magnetic resonance imaging (DWI) were employed before surgery. Diffusion-sensitive gradient b-values were taken at 400, 600, and 800 s/mm². Gross tumor volumes (GTV) were delineated using CT, T2-weighted MRI and DWI on different b-value images. GTV longitude length measured using the imaging modalities listed above was compared with pathologic lesion length to determine the most accurate imaging modality. CMS Xio radiotherapy planning system was used to fuse DWI scans and CT images to investigate the possibility of delineating GTV on fused images.

Results

The differences between the GTV length according to CT, T2-weighted MRI and pathology were 3.63 ± 12.06 mm and 3.46 ± 11.41 mm, respectively. When the diffusion-sensitive gradient b-value was 400, 600, and 800 s/mm², the differences between the GTV length using DWI and pathology were 0.73 ± 6.09 mm, -0.54 ± 6.03 mm and −1.58 ± 5.71 mm, respectively. DWI scans and CT images were fused accurately using the radiotherapy planning system. GTV margins were depicted clearly on fused images.

Conclusions

DWI displays esophageal SCC lengths most precisely when compared with CT or regular MRI. DWI scans fused with CT images can be used to improve accuracy to delineate GTV in esophageal SCC.

【 授权许可】

   
2013 Hou et al.; licensee BioMed Central Ltd.

【 图 表 】

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