The impact of mitochondrial function/dysfunction on IVF and new treatment possibilities for infertility

Reproductive Biology and Endocrinology

Randall Prather²  Qing-Yuan Sun¹  Heide Schatten³ 

[1]State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China

[2]Division of Animal Science, University of Missouri, Columbia 65211, USA

[3]Department of Veterinary Pathobiology, University of Missouri, Columbia, MO, USA

关键词: Infertility treatment;    Mitochondrial supplementation;    In vitro fertilization;    Metabolism;    Embryo development;    Embryos;    Oocytes;    Mitochondria;   

Others  :  1139727
DOI  :  10.1186/1477-7827-12-111

 received in 2014-07-17, accepted in 2014-09-04,  发布年份 2014

【 摘 要 】

Mitochondria play vital roles in oocyte functions and they are critical indicators of oocyte quality which is important for fertilization and development into viable offspring. Quality-compromised oocytes are correlated with infertility, developmental disorders, reduced blastocyst cell number and embryo loss in which mitochondrial dysfunctions play a significant role. Increasingly, women affected by metabolic disorders such as diabetes or obesity and oocyte aging are seeking treatment in IVF clinics to overcome the effects of adverse metabolic conditions on mitochondrial functions and new treatments have become available to restore oocyte quality. The past decade has seen enormous advances in potential therapies to restore oocyte quality and includes dietary components and transfer of mitochondria from cells with mitochondrial integrity into mitochondria-impaired oocytes. New technologies have opened up new possibilities for therapeutic advances which will increase the success rates for IVF of oocytes from women with compromised oocyte quality.

【 授权许可】

   
2014 Schatten et al.; licensee BioMed Central.

【 图 表 】

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