期刊论文详细信息
Particle and Fibre Toxicology
Can chemotherapy alone eliminate the transmission of soil transmitted helminths?
Roy M Anderson2  Simon J Brooker3  T Déirdre Hollingsworth1  James E Truscott2 
[1] Department of Clinical Sciences, Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK;Department of Infectious Disease Epidemiology, London Centre for Neglected Tropical Disease Research, School of Public Health, Faculty of Medicine, St Marys Campus, Imperial College London, Praed Street, London W2 1PG, UK;Kenya Medical Research Institute, Nairobi, Kenya
关键词: Mathematical modelling;    Elimination;    Chemotherapy;    Soil-transmitted helminths;   
Others  :  804391
DOI  :  10.1186/1756-3305-7-266
 received in 2014-02-14, accepted in 2014-06-03,  发布年份 2014
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【 摘 要 】

Background

Amongst the world’s poorest populations, availability of anthelmintic treatments for the control of soil transmitted helminths (STH) by mass or targeted chemotherapy has increased dramatically in recent years. However, the design of community based treatment programmes to achieve the greatest impact on transmission is still open to debate. Questions include: who should be treated, how often should they be treated, how long should treatment be continued for?

Methods

Simulation and analysis of a dynamic transmission model and novel data analyses suggest refinements of the World Health Organization guidelines for the community based treatment of STH.

Results

This analysis shows that treatment levels and frequency must be much higher, and the breadth of coverage across age classes broader than is typically the current practice, if transmission is to be interrupted by mass chemotherapy alone.

Conclusions

When planning interventions to reduce transmission, rather than purely to reduce morbidity, current school-based interventions are unlikely to be enough to achieve the desired results.

【 授权许可】

   
2014 Truscott et al.; licensee BioMed Central Ltd.

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