Role of Regulatory and Proinflammatory T-Cell Populations in Allergic Diseases

World Allergy Organization Journal

Hirohisa Saito³  Ruby Pawankar¹  Susumu Nakae³  Kanami Orihara² 

[1] The Department of Otolaryngology, Division of Rhinology and Allergy, Nippon Medical School, Tokyo, Japan;Department of Allergy and Immunology, National Research Institute for Child Health and Development, 2-10-1 Okura, Setagaya-ku 157-8535, Tokyo, Japan;The Atopy Research Center, Juntendo University

关键词: thymic stromal lymphopoietin;    mast cells;    interleukin 17;    regulatory T cells;    helper T cells;   

Others  :  825246
DOI  :  10.1097/wox.0b013e3181629ae3

 received in 2007-08-28, accepted in 2007-11-19,  发布年份 2008

【 摘 要 】

Regulatory T (T_reg) cells are considered to inhibit the development of both type 1 (T_h1) and type 2 helper T (T_h2) cells. However, it is recently reported that there are reduced numbers of T_reg cells in patients with allergic diseases as compared with individuals who have high levels of serum immunoglobulin E and blood eosinophils but are asymptomatic. Therefore, T_reg cells may suppress the onset of allergic disease by down-regulating other types of immune cells besides T_h1 and T_h2 cells. The newly discovered interleukin 17-producing helper T cells that are responsible for autoimmune inflammatory diseases may counteract T_reg cells even in allergic diseases. The T_h2 cells that are capable of producing of high levels of tumor necrosis factor-α may also be involved in inflammation in allergic diseases. In this review, we further discuss the role of T_h1, T_h2, interleukin 17-producing helper T cells, and T_reg cells in allergic diseases by using the balancing square model and the factors differentiating between patients with clinical manifestations of allergic symptomatic and atopic individuals who are sensitized but asymptomatic.

【 授权许可】

   
2008 World Allergy Organization; licensee BioMed Central Ltd.

【 图 表 】

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