Multidrug resistance ATP-binding cassette membrane transporters as targets for improving oropharyngeal candidiasis treatment

Advances in Cellular and Molecular Otolaryngology

Lorena Martinez¹  Pierre Falson¹ 

关键词: Allergic Rhinitis;    epithelium;    myeloid dendritic cell;    plasmacytoid dendritic cell;    thymic stromal lymphopoietin;   

DOI  :  

来源: Co-Action Publishing

【 摘 要 】

Oropharyngeal candidiasis is caused byCandida sp. , opportunistic yeasts that infect immunocompromised patients. Chemotherapies are based on antifungal drugs against which yeast overexpress and address to the plasma membrane ATP-binding cassette (ABC) pumps for expelling these drugs out of the cell. More critical—because these pumps translocate structurally unrelated drugs—they confer to the yeast a broad resistance to antifungals when expressed, hampering the efficacy of these treatments whatever the drug used. We review here the disease, its treatment, and the role played by multidrug resistance ABC, and strategies to overcome this problem. Keywords:oropharyngeal candidiasis; pathogenic yeasts; fungal drug resistance; drug efflux; ABC transporters; P-glycoprotein; CDR1(Published: 4 March 2014) Citation:Advances in Cellular and Molecular Otolaryngology 2014,2 : 23955 - http://dx.doi.org/10.3402/acmo.v2.23955

【 授权许可】

Unknown